火绒草全草中的生物活性成分
Bioactive constituents from the whole plants of Leontopodium leontopodioides (Wild.) Beauv.
作者信息
Chen Qiu, Li Jian, Ruan Jingya, Qu Lu, Wei Hongyan, Ma Xiaoling, Zhang Yi, Wang Tao
机构信息
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, China.
Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, China.
出版信息
J Nat Med. 2018 Jan;72(1):202-210. doi: 10.1007/s11418-017-1132-3. Epub 2017 Sep 21.
Five new compounds, leontoaerialosides A (1), B (2), C (3), D (4), and E (5) were obtained from the 70% EtOH extract of the whole plants of Leontopodium leontopodioides (Wild.) Beauv. Their structures were elucidated by chemical and spectroscopic methods. Moreover, compounds 4 and 5 showed significant effects on stimulating the hepatic glucose uptake in HepG2 cells.
从火绒草（Leontopodium leontopodioides (Wild.) Beauv.）全草的70%乙醇提取物中获得了5种新化合物，即火绒草苷A（1）、B（2）、C（3）、D（4）和E（5）。通过化学和光谱方法阐明了它们的结构。此外，化合物4和5对刺激HepG2细胞的肝脏葡萄糖摄取具有显著作用。
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