外泌体作为心血管疾病的诊断生物标志物
Exosomes as Diagnostic Biomarkers in Cardiovascular Diseases.
作者信息
Jansen Felix, Li Qian
机构信息
Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.
出版信息
Adv Exp Med Biol. 2017;998:61-70. doi: 10.1007/978-981-10-4397-0_4.
Exosomes play important roles in the development and progression of cardiovascular diseases by modulating intercellular communication. Contents and quantities of exosomes are variable under different pathological cardiovascular conditions. Based on these concepts, exosomes have been proposed as novel diagnostic biomarkers in cardiovascular diseases. However, many issues related with clinically applicable biomarkers remain unresolved. Within this chapter, we discuss the potential value, but also the current challenges using exosome numbers and contents as diagnostic and prognostic biomarker in diverse cardiovascular pathologies.
外泌体通过调节细胞间通讯在心血管疾病的发生和发展中发挥重要作用。在不同的病理性心血管疾病状态下，外泌体的内容物和数量是可变的。基于这些概念，外泌体已被提议作为心血管疾病的新型诊断生物标志物。然而，许多与临床应用生物标志物相关的问题仍未得到解决。在本章中，我们讨论了在外泌体数量和内容物作为各种心血管疾病的诊断和预后生物标志物方面的潜在价值，同时也讨论了当前面临的挑战。
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