Carton J A, Perez F, Maradona J A, Mendez F J
Infectious Disease Unit, Hospital Nuestra Señora de Covadonga, Universidad de Oviedo, Spain.
Eur J Clin Microbiol. 1987 Oct;6(5):578-80. doi: 10.1007/BF02014252.
Imipenem was successfully used to treat a case of subdural empyema complicated by multiple cerebral abscesses, in which surgery and therapy with other antibiotics had previously failed. Imipenem concentrations in serum, cerebrospinal fluid and the cerebral abscess were much higher than the MICs for the infecting organisms, qualifying this antibiotic as an effective option in therapy of suppurative intracranial infections.
亚胺培南成功用于治疗1例并发多发性脑脓肿的硬膜下积脓，此前手术及其他抗生素治疗均告失败。血清、脑脊液及脑脓肿中亚胺培南的浓度远高于感染菌的最低抑菌浓度（MIC），这表明该抗生素是治疗化脓性颅内感染的有效选择。
