Xu Chun-Hua, Yuan Qi, Yu Li-Ke, Wang Wei, Lin Yong
Endoscopic Center of Nanjing Chest Hospital, Nanjing, Jiangsu 210029, China.
Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu 210029, China.
Oncotarget. 2017 Apr 4;8(35):58272-58277. doi: 10.18632/oncotarget.16813. eCollection 2017 Aug 29.
The aim of this study was to assess the usefulness of endobronchial ultrasound transbronchial biopsy with guide-sheath (EBUS-GS-TBB) for the diagnosis of solitary pulmonary nodules (SPNs). One hundred and eighty patients, who were diagnosed with SPNs and underwent an endobronchial ultrasound procedure. The diagnostic yield, safety and the associated factors were analyzed. Mean EBUS-GS procedure time was 14±8 min. The average number of biopsy specimens obtained in each SPNs was 5±1.2. One hundred and thirty-four SPNs were diagnosed by EBUS-GS-TBB and the diagnostic rate was 74.4 %. The diagnosis rate of malignancy was 83.3 %, while that of benign disease was 56.7 %. The most important factors that helped enhance EBUS-GS diagnostic accuracy included lesion diameter greater than 20mm, EBUS probe within the lesions and central lesions. No pneumothorax, hemoptysis or other serious complications occurred with the diagnostic procedures. EBUS-GS-TBB is a safe and effective method for diagnosing SPNs.
本研究的目的是评估带鞘支气管内超声引导下经支气管针吸活检术（EBUS-GS-TBB）对孤立性肺结节（SPN）的诊断价值。180例被诊断为SPN的患者接受了支气管内超声检查。分析了诊断率、安全性及相关因素。EBUS-GS平均操作时间为14±8分钟。每个SPN获得的活检标本平均数量为5±1.2个。134个SPN通过EBUS-GS-TBB得以诊断，诊断率为74.4%。恶性病变的诊断率为83.3%，良性病变的诊断率为56.7%。有助于提高EBUS-GS诊断准确性的最重要因素包括病变直径大于20mm、EBUS探头位于病变内以及中央型病变。诊断过程中未发生气胸、咯血或其他严重并发症。EBUS-GS-TBB是诊断SPN的一种安全有效的方法。
