自闭症的社会认知与后上颞叶回的神经发育有关。
Social cognition in autism is associated with the neurodevelopment of the posterior superior temporal sulcus.
机构信息
UNIACT, Psychiatry Team, Neurospin Neuroimaging Platform, CEA Saclay, Gif-Sur-Yvette, France.
INSERM U955, Mondor Institute for Biomedical Research, Team 15, Translational Psychiatry, Créteil, France.
出版信息
Acta Psychiatr Scand. 2017 Nov;136(5):517-525. doi: 10.1111/acps.12814. Epub 2017 Sep 22.
OBJECTIVE
The posterior superior temporal sulcus (pSTS) plays a critical role in the 'social brain'. Its neurodevelopment and relationship with the social impairment in autism spectrum disorders (ASD) are not well understood. We explored the relationship between social cognition and the neurodevelopment of the pSTS in ASD.
METHOD
We included 44 adults with high-functioning ASD and 36 controls. We assessed their performances on the 'Reading the mind in the eyes' test (for 34 of 44 subjects with ASD and 30 of 36 controls), their fixation time on the eyes with eye tracking (for 35 of 44 subjects with ASD and 30 of 36 controls) and the morphology of the caudal branches of the pSTS (length and depth), markers of the neurodevelopment, with structural MRI.
RESULTS
The right anterior caudal ramus of the pSTS was significantly longer in patients with ASD compared with controls (52.6 mm vs. 38.3 mm; P = 1.4 × 10 ; Cohen's d = 0.76). Its length negatively correlated with fixation time on the eyes (P = 0.03) in the ASD group and with the 'Reading the mind in the eyes' test scores in both groups (P = 0.03).
CONCLUSION
Our findings suggest that the neurodevelopment of the pSTS is related to the ASD social impairments.
目的
后上颞沟（pSTS）在后脑“社交大脑”中起着关键作用。其神经发育及其与自闭症谱系障碍（ASD）社会障碍之间的关系尚未得到很好的理解。我们探讨了 ASD 中社会认知与 pSTS 神经发育之间的关系。
方法
我们纳入了 44 名高功能 ASD 成人和 36 名对照。我们评估了他们在“读眼神”测试中的表现（ASD 组中有 34 名受试者和对照组中有 30 名受试者），他们的眼跟踪注视时间（ASD 组中有 35 名受试者和对照组中有 30 名受试者）以及 pSTS 尾部分支的形态（长度和深度），这是神经发育的标志物，使用结构 MRI 进行评估。
结果
与对照组相比，ASD 患者的右侧 pSTS 前部尾支更长（52.6mm 与 38.3mm；P = 1.4×10；Cohen's d = 0.76）。其长度与 ASD 组的眼注视时间呈负相关（P = 0.03），与两组的“读眼神”测试分数呈负相关（P = 0.03）。
结论
我们的发现表明，pSTS 的神经发育与 ASD 的社交障碍有关。
Zotero 插件