Aram J A, Lodge D
Royal Veterinary College, London, U.K.
Neurosci Lett. 1987 Dec 29;83(3):345-50. doi: 10.1016/0304-3940(87)90112-1.
The effects of changing extracellular pH on epileptiform activity induced by the removal of magnesium ions from the perfusing medium were studied. The proportion of bicarbonate in the artificial cerebrospinal fluid and of CO2 in the gas mixture were altered to mimic metabolic and respiratory acid-base disturbances. Changes in pH of 0.2 unit from control produced marked effects. Epileptiform activity was enhanced by alkalosis and diminished by acidosis. In normal magnesium-containing medium metabolic alkalosis (pH greater than 7.8) induced spontaneous epileptiform activity that was blocked by selective N-methyl-D-aspartate antagonists. The relevance of these findings to acid/base changes in clinical epilepsy is discussed.
研究了改变细胞外pH值对因从灌注介质中去除镁离子而诱发的癫痫样活动的影响。改变人工脑脊液中碳酸氢盐的比例以及混合气体中二氧化碳的比例，以模拟代谢性和呼吸性酸碱紊乱。与对照相比，pH值变化0.2个单位产生了显著影响。碱中毒增强癫痫样活动，酸中毒则使其减弱。在正常含镁介质中，代谢性碱中毒（pH大于7.8）诱发自发癫痫样活动，该活动可被选择性N-甲基-D-天冬氨酸拮抗剂阻断。讨论了这些发现与临床癫痫中酸碱变化的相关性。
