Zhou Dexi, Chen Lu, Yang Kui, Jiang Hui, Xu Wenke, Luan Jiajie
Department of Pharmacy, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui Province, China.
Laboratory of Clinical Pharmacy, Wannan Medical College, Wuhu, Anhui Province, China.
Oncotarget. 2017 Aug 4;8(36):60710-60722. doi: 10.18632/oncotarget.19940. eCollection 2017 Sep 1.
The concept of macrophage polarization is defined in terms of macrophage phenotypic heterogeneity and functional diversity. Cytokines signals are thought to be required for the polarization of macrophage populations toward different phenotypes at different stages in development, homeostasis and disease. The suppressors of cytokine signaling family of proteins contribute to the magnitude and duration of cytokines signaling, which ultimately control the subtle adjustment of the balance between divergent macrophage phenotypes. This review highlights the specific roles and mechanisms of various cytokines family and their negative regulators link to the macrophage polarization programs. Eventually, breakthrough in the identification of these molecules will provide the novel therapeutic approaches for a host of diseases by targeting macrophage phenotypic shift.
巨噬细胞极化的概念是根据巨噬细胞的表型异质性和功能多样性来定义的。细胞因子信号被认为是巨噬细胞群体在发育、稳态和疾病的不同阶段向不同表型极化所必需的。细胞因子信号传导抑制蛋白家族有助于细胞因子信号传导的强度和持续时间，最终控制不同巨噬细胞表型之间平衡的微妙调节。本综述重点介绍了各种细胞因子家族及其负调控因子与巨噬细胞极化程序相关的具体作用和机制。最终，这些分子鉴定方面的突破将通过靶向巨噬细胞表型转变为一系列疾病提供新的治疗方法。
