a Department of Family Medicine , University of Manitoba , Winnipeg MB , Canada.
b Vaccine and Drug Evaluation Centre, Department of Community Health Sciences , University of Manitoba, University of Manitoba , Winnipeg MB , Canada.
Hum Vaccin Immunother. 2017 Nov 2;13(11):2669-2673. doi: 10.1080/21645515.2017.1370162. Epub 2017 Sep 26.
During the 2009 H1N1 pandemic, 99 severe respiratory illness (SRI) cases were reported in Manitoba. The cause of illness was often not established. Many of these cases may have been unidentified pH1N1. We conducted a chart audit of all severe SRI cases and compared their demographic and clinical characteristics to severe pH1N1 cases. 73 of the 170 cases reviewed were confirmed pH1N1, 53 were SRI with an identified cause, and 44 were SRI with no identified cause. Unexplained SRI cases were similar to pH1N1 cases in terms of risk factors, geographic and temporal distribution, clinical presentation and outcomes. We found that unexplained SRI cases often resembled severe pH1N1 cases, suggesting that these cases were at least in part caused by undiagnosed pH1N1. The overall impact of the pandemic may have been underestimated, especially among the most severely affected indigenous and northern communities.
在 2009 年 H1N1 大流行期间，马尼托巴省报告了 99 例严重呼吸道疾病（SRI）病例。病因往往未确定。这些病例中有许多可能是未被识别的 pH1N1。我们对所有严重 SRI 病例进行了图表审查，并将其人口统计学和临床特征与严重 pH1N1 病例进行了比较。在审查的 170 例病例中，有 73 例被确认为 pH1N1，53 例是有明确病因的 SRI，44 例是无明确病因的 SRI。不明原因的 SRI 病例在危险因素、地理和时间分布、临床表现和结果方面与 pH1N1 病例相似。我们发现，不明原因的 SRI 病例通常与严重 pH1N1 病例相似，这表明这些病例至少部分是由未被诊断的 pH1N1 引起的。大流行的总体影响可能被低估了，尤其是在受影响最严重的土著和北方社区。
