Gal Omer, Ishai Yael, Sulkes Aaron, Shochat Tzipora, Yerushalmi Rinat
Davidoff Cancer Center, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
Oncology. 2018;94(1):31-38. doi: 10.1159/000480087. Epub 2017 Sep 27.
The number of older adults diagnosed with breast cancer is increasing. However, data on breast cancer characteristics, treatment, and survival in elderly women are sparse.
The database of a tertiary cancer center was searched for all women aged ≥65 years who were diagnosed with early breast cancer in 2004-2007. Patients were divided into 2 age groups: 65-75 years and >75 years. Data on tumor, treatment, and outcome parameters were compared.
The cohort included 390 patients. The older group underwent more mastectomies but less axillary surgery or adjuvant systemic therapy. Median overall survival (OS) was 9.5 years in the older group and not reached in the younger group; the 8-year disease-free survival rates were 85 and 88%, respectively (p = 0.27). Both age and tumor subtype had an effect on OS and recurrence rates (p < 0.001 for OS; p = 0.16 for recurrence). The worst outcome was noted in women aged >75 years with triple-negative (TN) disease.
The treatment approach was different between both age groups, despite similar tumor characteristics. TN subtype presented as the most aggressive disease in both age groups. Physicians should be alert to these findings and select treatment on a case-by-case basis.
被诊断患有乳腺癌的老年成年人数量正在增加。然而，关于老年女性乳腺癌特征、治疗及生存情况的数据却很稀少。
在一家三级癌症中心的数据库中搜索2004年至2007年期间所有年龄≥65岁且被诊断为早期乳腺癌的女性。患者被分为两个年龄组：65 - 75岁和>75岁。对肿瘤、治疗及结局参数的数据进行比较。
该队列包括390名患者。年龄较大的组接受乳房切除术的比例更高，但腋窝手术或辅助全身治疗的比例更低。年龄较大组的中位总生存期（OS）为9.5年，年龄较小组未达到；8年无病生存率分别为85%和88%（p = 0.27）。年龄和肿瘤亚型均对总生存期和复发率有影响（总生存期p < 0.001；复发率p = 0.16）。在年龄>75岁的三阴性（TN）疾病女性中观察到最差的结局。
尽管肿瘤特征相似，但两个年龄组的治疗方法不同。TN亚型在两个年龄组中均表现为最具侵袭性的疾病。医生应留意这些发现并根据具体情况选择治疗方案。
