Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Center for Infection Control, National Taiwan University Hospital, Taipei, Taiwan.
J Microbiol Immunol Infect. 2019 Jun;52(3):487-493. doi: 10.1016/j.jmii.2017.08.017. Epub 2017 Sep 18.
Healthcare-associated infections caused by multidrug-resistant (MDR) pathogens are significantly associated with increased mortality and morbidity. Environmental cleaning can reduce transmission of these pathogens but is often inadequate. Adjunctive methods are warranted to enhance the effectiveness of disinfection particularly in hospital settings where healthcare-associated infections are of major concern.
We conducted a study to examine the effectiveness of a mobile, automatic device, Hyper Light Disinfection Robot (model: Hyper Light P3), which utilized ultraviolet-C (UV-C) to kill MDR-Pseudomonas aeruginosa, MDR- Acinetobacter baumannii, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE), Mycobacterium abscessus and Aspergillus fumigatus. The performance of this device in disinfecting hospital rooms previously admitted by patients harboring MRSA and VRE was also assessed.
Except for VRE and M. abscessus, more than 3 log reduction of vegetative bacteria colonies was observed after UV-C irradiation of 5 min at a distance of 3 m from the device. At the distance of 1 m, substantial and comparable reduction of colonies was observed across all tested microorganisms regardless of exposure time. The killing effect was less pronounced for A. fumigatus particularly at the distance of 2-3 m. In uncleaned hospital rooms, there was significant reduction in the number of bacteria colonies sampled from different surfaces after UV-C irradiation for 15 min.
UV-C disinfection system was effective in killing MDR pathogens. Further study is warranted to confirm its effectiveness as an adjunctive method in disinfecting hospital environment.
由多药耐药（MDR）病原体引起的医源性感染与死亡率和发病率的增加显著相关。环境清洁可以减少这些病原体的传播，但往往是不够的。需要辅助方法来增强消毒的效果，特别是在医院环境中，医源性感染是一个主要关注点。
我们进行了一项研究，以检验一种移动、自动的设备——Hyper Light 消毒机器人（型号：Hyper Light P3）的有效性，该设备利用紫外线-C（UV-C）杀死 MDR-铜绿假单胞菌、MDR-鲍曼不动杆菌、耐甲氧西林金黄色葡萄球菌（MRSA）、万古霉素耐药粪肠球菌（VRE）、脓肿分枝杆菌和烟曲霉。还评估了该设备在消毒先前收治 MRSA 和 VRE 患者的医院病房方面的性能。
除 VRE 和 M. abscessus 外，在距离设备 3 米处照射 5 分钟的 UV-C 后，观察到需氧菌菌落减少 3 个对数以上。在 1 米的距离，无论暴露时间如何，所有测试的微生物都观察到大量且相当的菌落减少。对于烟曲霉，特别是在 2-3 米的距离，杀菌效果不那么明显。在未清洁的医院病房中，在经过 15 分钟的 UV-C 照射后，从不同表面采集的细菌菌落数量显著减少。
UV-C 消毒系统在杀死 MDR 病原体方面是有效的。需要进一步的研究来确认其作为辅助方法在医院环境消毒中的有效性。
