• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

孟德尔随机化方法的挑战。

The challenge of Mendelian randomization approach.

机构信息

a CNR-IFC , Clinical Epidemiology of Renal Diseases and Hypertension , Reggio Calabria , Italy.

出版信息

Curr Med Res Opin. 2017 Nov;33(sup3):5-8. doi: 10.1080/03007995.2017.1378514.

DOI:10.1080/03007995.2017.1378514
PMID:28952387
Abstract

This review deals with methodological problems in current evidence that suggest links between gout and adverse cardiovascular (CV) outcomes and renal disease, and presents a recently adopted approach aimed at overcoming such drawbacks. The review aims to provide more reliable answers regarding the role of uric acid in the pathogenesis and progression of cardiovascular and renal events.

摘要

这篇综述探讨了目前关于痛风与不良心血管(CV)结局和肾脏疾病之间关联的证据中存在的方法学问题,并提出了一种最近采用的方法,旨在克服这些缺陷。本综述旨在为尿酸在心血管和肾脏事件的发病机制和进展中的作用提供更可靠的答案。

相似文献

1
The challenge of Mendelian randomization approach.孟德尔随机化方法的挑战。
Curr Med Res Opin. 2017 Nov;33(sup3):5-8. doi: 10.1080/03007995.2017.1378514.
2
The role of uric acid in the development of cardiovascular disease.尿酸在心血管疾病发展中的作用。
Curr Med Res Opin. 2015;31 Suppl 2:1-2. doi: 10.1185/03007995.2015.1087985.
3
[HYPERURICEMIA AND POTENTIAL RISK OF CARDIOVASCULAR AND RENAL DISEASES].[高尿酸血症与心血管疾病和肾脏疾病的潜在风险]
Rev Med Liege. 2016 May;71(5):262-8.
4
Asymptomatic hyperuricemia: perhaps not so benign?无症状性高尿酸血症:或许并非那么良性?
J Rheumatol. 2008 May;35(5):734-7.
5
Comment on: Gout: an independent risk factor for all-cause and cardiovascular mortality.评论:痛风:全因死亡率和心血管死亡率的独立危险因素。
Rheumatology (Oxford). 2010 Jul;49(7):1421-2; author reply 1422. doi: 10.1093/rheumatology/keq118. Epub 2010 Apr 27.
6
Cardiovascular and renal effects of hyperuricaemia and gout.高尿酸血症和痛风对心血管及肾脏的影响。
Reumatismo. 2012 Jan 19;63(4):253-62. doi: 10.4081/reumatismo.2011.253.
7
Inflammation: a possible mechanism for a causative role of hyperuricemia/gout in cardiovascular disease.炎症:高尿酸血症/痛风在心血管疾病中起致病作用的一种可能机制。
Curr Med Res Opin. 2015;31 Suppl 2:9-14. doi: 10.1185/03007995.2015.1087980.
8
Time to target uric acid to retard CKD progression.是时候将尿酸作为靶点来延缓慢性肾脏病的进展了。
Clin Exp Nephrol. 2017 Apr;21(2):182-192. doi: 10.1007/s10157-016-1288-2. Epub 2016 Jun 23.
9
The role of urate-lowering treatment on cardiovascular and renal disease: evidence from CARES, FAST, ALL-HEART, and FEATHER studies.降尿酸治疗在心血管和肾脏疾病中的作用:来自 CARES、FAST、ALL-HEART 和 FEATHER 研究的证据。
Curr Med Res Opin. 2017 Nov;33(sup3):27-32. doi: 10.1080/03007995.2017.1378523.
10
Detrimental role of hyperuricemia on the cardio-reno-vascular system.高尿酸血症对心血管系统的有害作用。
Curr Med Res Opin. 2015;31 Suppl 2:21-6. doi: 10.1185/03007995.2015.1087984.

引用本文的文献

1
Integrated multi-omics analysis reveals diagnostic biomarkers and therapeutic targets for systemic lupus erythematosus.综合多组学分析揭示系统性红斑狼疮的诊断生物标志物和治疗靶点。
Medicine (Baltimore). 2025 Aug 15;104(33):e42290. doi: 10.1097/MD.0000000000042290.
2
Causal relationship between hypertension and ischemic stroke: A two-sample Mendelian randomization study.高血压与缺血性中风之间的因果关系:一项两样本孟德尔随机化研究。
Brain Circ. 2024 Sep 26;10(3):257-264. doi: 10.4103/bc.bc_105_23. eCollection 2024 Jul-Sep.
3
The causal relationship between obesity, obstructive sleep apnea and atrial fibrillation: a study based on mediated Mendelian randomization.
肥胖、阻塞性睡眠呼吸暂停与心房颤动之间的因果关系:一项基于中介孟德尔随机化的研究
Front Cardiovasc Med. 2024 Apr 19;11:1406192. doi: 10.3389/fcvm.2024.1406192. eCollection 2024.
4
Application and discoveries of metabolomics and proteomics in the study of female infertility.代谢组学和蛋白质组学在女性不孕症研究中的应用与发现。
Front Endocrinol (Lausanne). 2024 Jan 10;14:1315099. doi: 10.3389/fendo.2023.1315099. eCollection 2023.
5
The immune factors have complex causal regulation effects on inflammatory bowel disease.免疫因素对炎症性肠病具有复杂的因果调节作用。
Front Immunol. 2024 Jan 9;14:1322673. doi: 10.3389/fimmu.2023.1322673. eCollection 2023.
6
Gut microbiota and common gastrointestinal diseases: a bidirectional two-sample Mendelian randomized study.肠道微生物群与常见胃肠道疾病:一项双向双样本孟德尔随机化研究
Front Microbiol. 2023 Nov 17;14:1273269. doi: 10.3389/fmicb.2023.1273269. eCollection 2023.
7
The causal relationship between circulating cytokines and critically ill COVID-19: A bidirectional Mendelian randomization analysis.循环细胞因子与危重症 COVID-19 之间的因果关系:双向孟德尔随机化分析。
J Glob Health. 2022 Feb 19;12:05010. doi: 10.7189/jogh.12.05010. eCollection 2022.