Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología, Secretaría de Salud, 11000 Ciudad de México, Mexico.
Sección de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, 11340 Ciudad de México, Mexico.
Nutrients. 2017 Sep 27;9(10):1067. doi: 10.3390/nu9101067.
: Gestational weight gain is an important modifiable factor known to influence fetal outcomes including birth weight and adiposity. Leptin is normally correlated with adiposity and is also known to increase throughout pregnancy, as the placenta becomes a source of leptin synthesis. Several studies have reported positive correlations between cord blood leptin level and either birthweight or size for gestational age, as well as body mass index (BMI). : To determine the correlation of prenatal leptin concentration in pregnant adolescents with their gestational weight gain, postpartum weight retention, and weight/length of their newborn. : A cohort study was conducted on pregnant Mexican adolescents from Gestational Week 26-28 to three months postpartum ( = 168 mother-child dyads). An anthropometric assessment was made of each pregnant adolescent, and the serum level of leptin and the intake of energy were determined. The newborn was evaluated each month during postpartum. Clinical records were reviewed to obtain sociodemographic data. Bivariate correlations, tests for repeating measurements and logistic regression models were performed. : Leptin concentration gradually increased during the third trimester of pregnancy. At Gestation Week 36, leptin level correlated with gestational weight gain. When comparing adolescents that had the lowest and highest concentration of leptin, the former presented a mean of 6 kg less in gestational weight gain (inter-subject leptin concentration, = 0.001; inter-subject energy intake, = 0.497). Leptin concentration and gestational weight gain exerted an effect on the weight of the newborn (inter-subject leptin concentration for Week 32, = 0.024; inter-subject gestational weight gain, = 0.011). Newborn length was associated with leptin concentration at Week 28 (leptin effect, = 0.003; effect of gestational weight gain, = 0.722). : Pregnant adolescents with leptin concentration over 20 ng/mL showed a greater gestational weight gain. Leptin concentration correlated with length and weight of the newborn.
: 妊娠体重增加是一个重要的可改变因素，已知它会影响胎儿的结局，包括出生体重和肥胖程度。瘦素通常与肥胖程度相关，也已知在怀孕期间会增加，因为胎盘成为瘦素合成的来源。几项研究报告了脐带血瘦素水平与出生体重或胎龄大小以及体重指数（BMI）之间的正相关关系。: 目的：确定孕妇青少年产前瘦素浓度与其妊娠体重增加、产后体重滞留以及新生儿体重/长度的相关性。: 对妊娠 26-28 周至产后 3 个月的墨西哥青少年孕妇进行了队列研究（= 168 对母婴对子）。对每位孕妇青少年进行了人体测量评估，并确定了血清瘦素水平和能量摄入。新生儿在产后每月进行评估。查阅临床记录以获取社会人口统计学数据。进行了双变量相关性、重复测量检验和逻辑回归模型检验。: 瘦素浓度在妊娠晚期逐渐增加。在第 36 孕周时，瘦素水平与妊娠体重增加相关。在比较瘦素浓度最低和最高的青少年时，前者的妊娠体重增加少了 6 公斤（个体内瘦素浓度，= 0.001；个体内能量摄入，= 0.497）。瘦素浓度和妊娠体重增加对新生儿体重有影响（第 32 周个体内瘦素浓度，= 0.024；个体内妊娠体重增加，= 0.011）。新生儿长度与第 28 周的瘦素浓度相关（瘦素效应，= 0.003；妊娠体重增加的效应，= 0.722）。: 瘦素浓度超过 20ng/mL 的孕妇青少年妊娠体重增加较多。瘦素浓度与新生儿的长度和体重相关。
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