Bu Xiaolin, Fan Juan, Hu Xiaoli, Bi Xinling, Peng Bin, Zhang Denghai
Department of Dermatology at Shanghai Gongli Hospital - Second Military Medical University - Shanghai, China.
Department of Dermatology at Changhai Hospital - Second Military Medical University - Shanghai, China.
An Bras Dermatol. 2017 Jul-Aug;92(4):556-558. doi: 10.1590/abd1806-4841.20174946.
We report an 80-year-old male patient with severe rheumatoid arthritis who was treated with tripterygium glycoside, an immunosuppressive agent made from the extract of a Chinese medicinal herb called Tripterygium wilfordii Hook F. The patient had no apparent skin lesions before the treatment, but he developed aggressive hyperkeratotic lesions with rapid progression after using tripterygium glycoside. He was repeatedly diagnosed with eczema, but treatment failed to achieve efficacy. Interestingly, a microscopic examination of the lesions revealed numerous scabies mites and eggs. Thus, we confirmed the diagnosis of Norwegian scabies infection. Treated with crotamiton 10% cream and 10% sulfur ointment for one month, the patient's clinical symptoms disappeared.
我们报告了一名80岁的男性重症类风湿关节炎患者，他接受了雷公藤多苷治疗，这是一种由中药雷公藤提取物制成的免疫抑制剂。治疗前患者无明显皮肤病变，但使用雷公藤多苷后出现了进展迅速的侵袭性角化过度病变。他多次被诊断为湿疹，但治疗均未起效。有趣的是，病变的显微镜检查发现了大量疥螨和虫卵。因此，我们确诊为挪威疥疮感染。患者使用10%克罗米通乳膏和10%硫磺软膏治疗一个月后，临床症状消失。
