a Department of Medical IT Convergence Engineering , Kumoh National Institute of Technology , Gumi , Korea.
b Department of Optical System Engineering , Kumoh National Institute of Technology , Gumi , Korea.
Comput Assist Surg (Abingdon). 2017 Dec;22(sup1):79-85. doi: 10.1080/24699322.2017.1379158. Epub 2017 Sep 28.
Light sources such as laser and light emitting diode or ultrasound devices have been widely used for cancer therapy and regenerative medicines, since they are more cost-effective and less harmful than radiation therapy, chemotherapy or magnetic treatment. Compared to laser and low intensity ultrasound techniques, light emitting diode and high frequency focused ultrasound shows enhanced therapeutic effects, especially for small tumors.
We propose combinational light emitting diode-high frequency focused ultrasound treatment for human cervical cancer HeLa cells. Individual red, green, and blue light emitting diode light only, high frequency focused ultrasound only, or light emitting diode light combined with high frequency focused ultrasound treatments were applied in order to characterize the responses of HeLa cells.
Cell density exposed by blue light emitting diode light combined with high frequency focused ultrasound (2.19 ± 0.58%) was much lower than that of cells exposed by red and green light emitting diode lights (81.71 ± 9.92% and 61.81 ± 4.09%), blue light emitting diode light (11.19 ± 2.51%) or high frequency focused ultrasound only (9.72 ± 1.04%).
We believe that the proposed combinational blue light emitting diode-high frequency focused ultrasound treatment could have therapeutic benefits to alleviate cancer cell proliferation.
由于光疗、光动力疗法比放射疗法、化学疗法或磁疗更经济实惠且危害更小，因此激光、发光二极管或超声设备等光源已被广泛应用于癌症治疗和再生医学。与激光和低强度超声技术相比，发光二极管和高频聚焦超声显示出更强的治疗效果，尤其适用于小肿瘤。
我们提出了组合式发光二极管-高频聚焦超声治疗人宫颈癌细胞 HeLa 的方法。单独的红、绿、蓝光发光二极管光，高频聚焦超声或发光二极管光联合高频聚焦超声治疗分别应用于 HeLa 细胞，以研究 HeLa 细胞的反应。
与红、绿光发光二极管光（81.71±9.92%和 61.81±4.09%）、蓝光发光二极管光（11.19±2.51%）或单独的高频聚焦超声（9.72±1.04%）相比，暴露于蓝光发光二极管光联合高频聚焦超声的细胞密度（2.19±0.58%）明显更低。
我们相信，所提出的组合式蓝光发光二极管-高频聚焦超声治疗可能具有缓解癌细胞增殖的治疗益处。
