Lundgren S, Rosenquist J B
Int J Oral Maxillofac Surg. 1986 Oct;15(5):541-8. doi: 10.1016/s0300-9785(86)80056-4.
In a randomized cross-over study on sedation in outpatient oral surgery, intravenous and rectal administration of diazepam were compared. The mean dose for intravenous diazepam was 0.22 mg X kg-1 (range 0.15-0.38) and for rectal diazepam 0.58 mg X kg-1 (range 0.50-0.71). The determining factors for the patients' preference for sedation method, apprehension, effect produced by the sedative, recovery from sedation and the postoperative course were studied. The patients preferred the session in which they experienced stronger effect, regardless of the route of administration. Patient preference for sedation method did not differ when optimal dose regimens were used, and a preset dose of 10 mg rectal diazepam did not produce the desired effect. Apprehension was significantly higher prior to and during the first operation than the second operation, and all patients recovered from sedation within 2 1/2 hours after the administration.
在一项关于门诊口腔手术镇静的随机交叉研究中，比较了地西泮的静脉注射和直肠给药。静脉注射地西泮的平均剂量为0.22毫克×千克-1（范围0.15 - 0.38），直肠给药地西泮的平均剂量为0.58毫克×千克-1（范围0.50 - 0.71）。研究了患者对镇静方法的偏好、焦虑程度、镇静剂产生的效果、镇静恢复情况以及术后过程的决定因素。无论给药途径如何，患者更喜欢他们体验到更强效果的那一次。当使用最佳剂量方案时，患者对镇静方法的偏好没有差异，并且预先设定的10毫克直肠地西泮剂量未产生预期效果。第一次手术前和手术期间的焦虑程度明显高于第二次手术，所有患者在给药后2个半小时内从镇静状态恢复。
