一株源自一名成人T细胞白血病患者、在14号染色体q11断裂带存在染色体畸变的B细胞系。
A B-cell line having chromosome 14 aberration at break band q11 derived from an adult T-cell leukemia patient.
作者信息
Miyamoto K, Matsuoka M, Tomita N, Suzuki C, Sato Y, Ishii A, Kitajima K, Nonaka H, Kondo T, Hiraki Y
机构信息
School of Health Sciences, Okayama University.
出版信息
Jpn J Cancer Res. 1988 Jan;79(1):12-6. doi: 10.1111/j.1349-7006.1988.tb00004.x.
A B-cell line having translocations of chromosome 14 at break band q11 (the assigned locus of the alpha-chain gene of the T-cell antigen receptor) and chromosome 3 at break band p25 (the assigned locus of the c-raf-1 oncogene) was established from peripheral blood leukocytes of an adult T-cell leukemia (ATL) patient. The same chromosome 14 aberration at break band q11 and chromosome 3 aberration at break band p25 were also found in fresh T-cell leukemia cells. The B-cell line is surface immunoglobulin (sIg)+, immunoglobulin gene rearrangement+, ATL-specific antigen (ATLA)+, HTLV-1 proviral genome+, Epstein-Barr virus (EBV)-associated nuclear antigen (EBNA)+ and the EBV DNA genome+. The fresh T-leukemic cells were T-cell receptor gene rearrangement+, the HTLV-1 proviral genome+ and EBV DNA genome.
从一名成人T细胞白血病（ATL）患者的外周血白细胞中建立了一个B细胞系，该细胞系存在14号染色体在断裂带q11（T细胞抗原受体α链基因的指定位点）和3号染色体在断裂带p25（c-raf-1癌基因的指定位点）的易位。在新鲜的T细胞白血病细胞中也发现了14号染色体在断裂带q11的相同畸变以及3号染色体在断裂带p25的畸变。该B细胞系表面免疫球蛋白（sIg）阳性、免疫球蛋白基因重排阳性、ATL特异性抗原（ATLA）阳性、HTLV-1前病毒基因组阳性、爱泼斯坦-巴尔病毒（EBV）相关核抗原（EBNA）阳性以及EBV DNA基因组阳性。新鲜的T白血病细胞T细胞受体基因重排阳性、HTLV-1前病毒基因组阳性以及EBV DNA基因组阳性。
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