Ha Vanessa, Viguiliouk Effie, Kendall Cyril W C, Balachandran Bashyam, Jenkins David J A, Kavsak Peter A, Sievenpiper John L
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.
Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.
Clin Biochem. 2017 Dec;50(18):1104-1109. doi: 10.1016/j.clinbiochem.2017.09.021. Epub 2017 Sep 25.
Markers of subclinical cardiac injury are elevated in individuals with type 2 diabetes mellitus (T2DM) compared to healthy individuals. Low glycemic index (LGI) diets may improve both diabetes and cardiovascular risk but their effects on cardiac injury and fibrosis have not been previously studied. To test the effect of a LGI diet on markers of subclinical cardiac injury and fibrosis, we assessed the effect of a LGI compared with a high-cereal fibre diet on high-sensitivity cardiac troponin I (hs-cTnI) and galectin-3 in otherwise healthy individuals with T2DM in an exploratory analysis of a completed randomized trial.
A total of 201 participants completed the trial and had measurements of hs-cTnI and galectin-3 at baseline and at trial completion. Participants were randomized to follow a LGI or a high-cereal fibre diet over a 6-month period. Treatment differences were tested using Analysis of Covariance (ANCOVA) with sex, baseline values, and diet x sex interaction included as covariates.
In a completer's analysis, no significant differences were observed for change in hs-cTnI (-0.16ng/L vs. -0.22ng/L, p=0.713) and galectin-3 levels (0.64μg/L vs. 0.14μg/L, p=0.166) when a LGI diet was compared to a high-cereal fibre diet.
The effect of a LGI diet was similar to a high-cereal fibre diet on hs-cTnI and galectin-3 levels in otherwise healthy individuals with T2DM over a 6-month period. Nevertheless, in the absence of any adverse effects, LGI diets remain an option for diabetes and cardiovascular disease risk management. ClinicalTrials.gov identifier: NCT00438698.
与健康个体相比，2型糖尿病（T2DM）患者亚临床心脏损伤标志物水平升高。低血糖指数（LGI）饮食可能改善糖尿病和心血管疾病风险，但此前尚未研究其对心脏损伤和纤维化的影响。为了测试LGI饮食对亚临床心脏损伤和纤维化标志物的影响，我们在一项已完成的随机试验的探索性分析中，评估了LGI饮食与高谷物纤维饮食对T2DM健康个体高敏心肌肌钙蛋白I（hs-cTnI）和半乳糖凝集素-3的影响。
共有201名参与者完成了试验，并在基线和试验结束时测量了hs-cTnI和半乳糖凝集素-3。参与者被随机分配在6个月内遵循LGI饮食或高谷物纤维饮食。使用协方差分析（ANCOVA）测试治疗差异，将性别、基线值和饮食×性别交互作用作为协变量。
在完成者分析中，将LGI饮食与高谷物纤维饮食相比时，hs-cTnI变化（-0.16ng/L对-0.22ng/L，p = 0.713）和半乳糖凝集素-3水平（0.64μg/L对0.14μg/L，p = 0.166）未观察到显著差异。
在6个月期间，LGI饮食对T2DM健康个体hs-cTnI和半乳糖凝集素-3水平的影响与高谷物纤维饮食相似。然而，在没有任何不良影响的情况下，LGI饮食仍然是糖尿病和心血管疾病风险管理的一种选择。ClinicalTrials.gov标识符：NCT00438698。
