Kohli Gurjeet S, Haslauer Kristina, Sarowar Chowdhury, Kretzschmar Anna Liza, Boulter Mark, Harwood D Tim, Laczka Olivier, Murray Shauna A
Climate Change Cluster, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Sydney Institute of Marine Science, Chowder Bay Rd., Mosman, NSW 2088, Australia.
Toxicol Rep. 2017 Jun 15;4:328-334. doi: 10.1016/j.toxrep.2017.06.006. eCollection 2017.
Ciguatera Fish Poisoning (CFP) is a tropical disease caused by the consumption of fish contaminated with ciguatoxins (CTXs). Currently, the only feasible prevention methods for CFP are to avoid the consumption of fish of certain species from some regions, avoid larger fish of certain species, or avoid all fish caught from specific regions. Here, we quantified levels of P-CTX-1B in Spanish Mackerel (), which is the main fish species that causes CFP in New South Wales and Queensland, Australia, using LC-MS detection against a toxin standard. We found detectable P-CTX-1B in both flesh and liver tissues in fish from New South Wales (n = 71, 1.4% prevalence rate, with a confidence interval of 1%-4%, and 7% prevalence, 1%-12%, in flesh and liver, respectively). In the small sample of fish from Queensland, there was a 46% prevalence (19-73%, n = 13). Toxin levels found were 0.13 μg kg to <0.1 μg kg in flesh, and 1.39 μg kg to <0.4 μg kg in liver, indicating that liver tissue had a significantly higher concentration (∼5 fold) of P-CTX-1B. No apparent relationship was observed between the length or weight of and the detection of P-CTX-1B in this study. Footnote.
雪卡鱼中毒（CFP）是一种热带疾病，由食用受雪卡毒素（CTXs）污染的鱼类引起。目前，CFP唯一可行的预防方法是避免食用某些地区特定种类的鱼类、避免食用某些种类的大鱼，或避免食用从特定地区捕获的所有鱼类。在此，我们使用液相色谱 - 质谱检测法，以毒素标准品对澳大利亚新南威尔士州和昆士兰州导致CFP的主要鱼类品种西班牙鲭鱼中的P - CTX - 1B水平进行了定量分析。我们发现新南威尔士州的鱼类肌肉和肝脏组织中均能检测到P - CTX - 1B（n = 71，检出率为1.4%，置信区间为1% - 4%，肌肉和肝脏中的检出率分别为7%，1% - 12%）。在昆士兰州的小样本鱼类中，检出率为46%（19 - 73%，n = 13）。肌肉中检测到的毒素水平为0.13 μg/kg至<0.1 μg/kg，肝脏中为1.39 μg/kg至<0.4 μg/kg，表明肝脏组织中P - CTX - 1B的浓度显著更高（约5倍）。在本研究中，未观察到西班牙鲭鱼的长度或重量与P - CTX - 1B的检测之间存在明显关系。脚注。
