White S R, Penner J D, Speth R C, Chan J Y
Department of Veterinary and Comparative Anatomy, Washington State University, Pullman 99164-6520.
Brain Res. 1988 Feb 16;441(1-2):195-201. doi: 10.1016/0006-8993(88)91398-4.
Locations of cells responsive to microiontophoretically applied angiotensin II (AII) were compared to distributions of AII receptor binding sites identified by autoradiography in the lumbar enlargement region of the rat spinal cord. Angiotensin II receptor binding sites were densely concentrated in the superficial layers of the dorsal horn. Considerably lower densities of binding sites were present in the remaining gray matter. Effects of microiontophoretically applied AII on lumbar spinal cord cells did not vary with location within the gray matter. AII facilitated firing of most cells in the lumbar cord whether the cells were in superficial or deeper laminae of the dorsal horn or in the ventral horn. The distribution of AII binding sites and the distribution of cells that were responsive to AII suggest that AII may play a role in modulating both sensory and motor functions of the spinal cord.
将对微量离子导入法施加的血管紧张素II（AII）产生反应的细胞位置，与通过放射自显影术确定的大鼠脊髓腰膨大区域AII受体结合位点的分布进行了比较。血管紧张素II受体结合位点密集地集中在背角的表层。其余灰质中的结合位点密度则低得多。微量离子导入法施加的AII对腰脊髓细胞的作用并不随灰质内位置的不同而变化。无论细胞位于背角的表层或深层还是腹角，AII都会促进腰脊髓中大多数细胞的放电。AII结合位点的分布以及对AII产生反应的细胞的分布表明，AII可能在调节脊髓的感觉和运动功能中发挥作用。
