Moeller I, Chai S Y, Oldfield B J, McKinley M J, Casley D, Mendelsohn F A
Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia.
Brain Res. 1995 Dec 1;701(1-2):301-6. doi: 10.1016/0006-8993(95)01128-0.
In the sheep spinal cord, a high density of [125I]angiotensin IV binding sites was localized to the perikaryon and processes of all somatic motor neurons, the autonomic motor neurons in the lateral horns of thoracic and lumbar segments and all dorsal root ganglia, but was low in lamina II of all dorsal horns. At supraspinal levels, [125I]angiotensin IV binding was abundant in numerous motor associated regions, with weaker binding observed in the sensory regions. This wide distribution pattern suggests an important role for the binding site in the central nervous system.
在绵羊脊髓中，高密度的[125I]血管紧张素IV结合位点定位于所有躯体运动神经元的胞体和突起、胸段和腰段侧角的自主运动神经元以及所有背根神经节，但在所有背角的II层中含量较低。在脊髓上水平，[125I]血管紧张素IV结合在许多运动相关区域丰富，而在感觉区域结合较弱。这种广泛的分布模式表明结合位点在中枢神经系统中起重要作用。
