Division of Biomedical Sciences, Faculty of Dentistry, McGill University, Montreal, H3A 1G1 QC, Canada.
Division of Orthodontics, Faculty of Dentistry, Toronto University, Toronto, M5G 1G6 ON, Canada.
Adv Healthc Mater. 2017 Oct;6(20). doi: 10.1002/adhm.201700549. Epub 2017 Sep 27.
Percutaneous and permucosal devices such as catheters, infusion pumps, orthopedic, and dental implants are commonly used in medical treatments. However, these useful devices breach the soft tissue barrier that protects the body from the outer environment, and thus increase bacterial infections resulting in morbidity and mortality. Such associated infections can be prevented if these devices are effectively integrated with the surrounding soft tissue, and thus creating a strong seal from the surrounding environment. However, so far, there are no percutaneous/permucosal medical devices able to prevent infection by achieving strong integration at the soft tissue-device interface. This review gives an insight into the current status of research into soft tissue-implant interface and the challenges associated with these interfaces. Biological soft/hard tissue interfaces may provide insights toward engineering better soft tissue interfaces around percutaneous devices. In this review, focus is put on the history and current findings as well as recent progress of the strategies aiming to develop a strong soft tissue seal around osseointegrated implants, such as orthopedic and dental implants.
经皮和经黏膜装置，如导管、输液泵、矫形和牙科植入物，常用于医疗治疗。然而，这些有用的装置会破坏保护身体免受外部环境侵害的软组织屏障，从而增加细菌感染，导致发病率和死亡率。如果这些装置能够有效地与周围的软组织结合，并与周围环境形成强大的密封，就可以预防这些相关感染。然而，到目前为止，还没有能够通过在软组织-装置界面实现牢固整合来预防感染的经皮/经黏膜医疗器械。这篇综述深入探讨了目前在软组织-植入物界面研究方面的现状以及这些界面所面临的挑战。生物软/硬组织界面可能为工程设计提供更好的围绕经皮装置的软组织界面提供了思路。在这篇综述中，重点介绍了旨在开发骨整合植入物（如矫形和牙科植入物）周围牢固软组织密封的策略的历史和当前发现以及最近进展。
