Guo Tianqi, Gulati Karan, Arora Himanshu, Han Pingping, Fournier Benjamin, Ivanovski Sašo
The University of Queensland, School of Dentistry, Herston QLD 4006, Australia.
The University of Queensland, School of Dentistry, Herston QLD 4006, Australia.
Acta Biomater. 2021 Apr 1;124:33-49. doi: 10.1016/j.actbio.2021.01.001. Epub 2021 Jan 12.
Osseointegration at the bone-implant interface and soft tissue integration (STI) at the trans-mucosal region are crucial for the long-term success of dental implants, especially in compromised patient conditions. The STI quality of conventional smooth and bio-inert titanium-based implants is inferior to that of natural tissue (i.e. teeth), and hence various surface modifications have been suggested. This review article compares and contrasts the various modification strategies (physical, chemical and biological) utilized to enhance STI of Ti implants. It also details the STI challenges associated with conventional Ti-based implants, current surface modification strategies and cutting-edge nano-engineering solutions. The topographical, biological and therapeutic advances achievable via electrochemically anodized Ti implants with TiO nanotubes/nanopores are highlighted. Finally, the status and future directions of such nano-engineered implants is discussed, with emphasis on bridging the gap between research and clinical translation.
骨-种植体界面的骨结合以及经黏膜区域的软组织结合（STI）对于牙种植体的长期成功至关重要，尤其是在患者条件不佳的情况下。传统光滑且生物惰性的钛基种植体的STI质量低于天然组织（即牙齿），因此人们提出了各种表面改性方法。这篇综述文章比较并对比了用于增强钛种植体STI的各种改性策略（物理、化学和生物）。它还详细阐述了与传统钛基种植体相关的STI挑战、当前的表面改性策略以及前沿的纳米工程解决方案。重点介绍了通过具有TiO纳米管/纳米孔的电化学阳极氧化钛种植体可实现的形貌、生物学和治疗方面的进展。最后，讨论了此类纳米工程种植体的现状和未来方向，重点是弥合研究与临床转化之间的差距。
