Wang Fang, Guan Shiwei, Xing Min, Qian Wenhao, Qiu Jiajun, Liu Xuanyong
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, PR China.
Bioact Mater. 2024 May 23;39:224-238. doi: 10.1016/j.bioactmat.2024.05.029. eCollection 2024 Sep.
Transcutaneous implants that penetrate through skin or mucosa are susceptible to bacteria invasion and lack proper soft tissue sealing. Traditional antibacterial strategies primarily focus on bacterial eradication, but excessive exposure to bactericidal agents can induce noticeable tissue damage. Herein, a rechargeable model (HPI-Ti) was constructed using perylene polyimide, an aqueous battery material, achieving temporal-sequence regulation of bacterial killing and soft tissue sealing. Charge storage within HPI-Ti is achieved after galvanostatic charge, and chemical discharge is initiated when immersed in physiological environments. During the early discharge stage, post-charging HPI-Ti demonstrates an antibacterial rate of 99.96 ± 0.01 % for 24 h, preventing biofilm formation. Contact-dependent violent electron transfer between bacteria and the material causes bacteria death. In the later discharge stage, the attenuated discharging status creates a gentler electron-transfer micro-environment for fibroblast proliferation. After discharge, the antibacterial activity can be reinstated by recharge against potential reinfection. The antibacterial efficacy and soft tissue compatibility were verified . These results demonstrate the potential of the charge-transfer-based model in reconciling antibacterial efficacy with tissue compatibility.
穿透皮肤或粘膜的经皮植入物易受细菌入侵，且缺乏适当的软组织密封。传统的抗菌策略主要集中在细菌根除上，但过度暴露于杀菌剂会导致明显的组织损伤。在此，使用水性电池材料苝聚酰亚胺构建了一种可充电模型（HPI-Ti），实现了细菌杀灭和软组织密封的时间序列调控。在恒电流充电后，HPI-Ti实现电荷存储，当浸入生理环境中时开始化学放电。在放电早期，充电后的HPI-Ti在24小时内表现出99.96±0.01%的抗菌率，可防止生物膜形成。细菌与材料之间的接触依赖性剧烈电子转移导致细菌死亡。在放电后期，减弱的放电状态为成纤维细胞增殖创造了更温和的电子转移微环境。放电后，可通过充电恢复抗菌活性以应对潜在的再感染。抗菌效果和软组织相容性得到了验证。这些结果证明了基于电荷转移的模型在协调抗菌效果与组织相容性方面的潜力。
