School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado.
Department of Mechanical Engineering, Colorado State University, Fort Collins, Colorado.
J Biomed Mater Res B Appl Biomater. 2018 Jul;106(5):1964-1975. doi: 10.1002/jbm.b.34010. Epub 2017 Sep 30.
Despite their overall success, different blood-contacting medical devices such as heart valves, stents, and so forth, are still plagued with hemocompatibility issues which often result in the need for subsequent replacement and/or life-long anticoagulation therapy. Consequently, there is a significant interest in developing biomaterials that can address these issues. Polymeric-based materials have been proposed for use in many applications due to their ability to be finely tuned through manufacturing and surface modification to enhance hemocompatibility. In this study, we have developed a novel, hydrophilic biomaterial comprised of an interpenetrating polymer network (IPN) of hyaluronan (HA) and linear low density polyethylene (LLDPE). HA is a highly lubricous, anionic polysaccharide ubiquitously found in the human body. It is currently being investigated for a vast array of biomedical applications including cardiovascular therapies such as hydrogel-based regenerative cell therapies for myocardial infarction, HA-coated stents, and surface modifications of polyurethane and metals for use in blood-contacting implants. The aim of this study was to assess the in vitro thrombogenic response of the hydrophilic polymer surface, HA-LLDPE for future potential use as flexible heart valve leaflets. The results indicate that HA-LLDPE is non-toxic and reduces thromobogenicity as compared to LLDPE surfaces, asserting its feasibility for use as a blood-contacting biomaterial. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1964-1975, 2018.
尽管它们总体上取得了成功，但不同的接触血液的医疗设备，如心脏瓣膜、支架等，仍然存在血液相容性问题，这往往导致需要后续更换和/或终身抗凝治疗。因此，人们对开发能够解决这些问题的生物材料有着浓厚的兴趣。由于能够通过制造和表面改性进行精细调整以提高血液相容性，基于聚合物的材料已被提议用于许多应用中。在这项研究中，我们开发了一种新型的亲水性生物材料，由透明质酸（HA）和线性低密度聚乙烯（LLDPE）的互穿聚合物网络（IPN）组成。HA 是一种高度润滑的阴离子多糖，在人体中广泛存在。它目前正在被广泛研究用于各种生物医学应用，包括心血管疗法，如基于水凝胶的心肌梗死再生细胞疗法、HA 涂层支架以及用于接触血液植入物的聚氨酯和金属的表面改性。本研究的目的是评估亲水性聚合物表面 HA-LLDPE 的体外血栓形成反应，以评估其未来作为柔性心脏瓣膜叶的潜在用途。结果表明，HA-LLDPE 无毒，与 LLDPE 表面相比降低血栓形成性，证明其作为血液接触生物材料的可行性。© 2017 威利父子公司。生物医学材料研究杂志 B：应用生物材料，106B：1964-1975，2018 年。
