McConaghy N, Blaszczynski A, Kidson W
Department of Psychiatry, Prince of Wales Hospital, Sydney, Australia.
Acta Psychiatr Scand. 1988 Feb;77(2):199-206. doi: 10.1111/j.1600-0447.1988.tb05101.x.
Thirty sex offenders were randomly allocated: 10 to receive medroxyprogesterone therapy (M), 10, imaginal desensitization (ID) and 10 both (ID + M). Twenty-four responded for one year though 3 subsequently relapsed. There were no significant differences in response to the 3 treatments. Four patients who did not respond to the initial treatment and the 3 who relapsed responded to further treatment. Most treated with M maintained heterosexual intercourse at pretreatment frequency. Self-reported reduction in anomalous sexual urges in patients receiving M correlated with reduced testosterone levels one month following treatment, demonstrating that the response was specific and validating the assessment by patients' self-reports. Where cost-effectiveness or time constraints are factors influencing treatment of sex offenders, one of these therapies warrants consideration.
30名性犯罪者被随机分配：10人接受甲羟孕酮治疗（M），10人接受想象脱敏疗法（ID），10人同时接受两种治疗（ID + M）。24人维持了一年的疗效，不过后来有3人复发。三种治疗方法的疗效无显著差异。4名对初始治疗无反应的患者和3名复发患者对进一步治疗有反应。大多数接受M治疗的患者维持了治疗前频率的异性性交。接受M治疗的患者自我报告异常性冲动减少，与治疗后一个月睾酮水平降低相关，表明该反应具有特异性，并验证了患者自我报告的评估。在成本效益或时间限制是影响性犯罪者治疗的因素时，这些疗法中的一种值得考虑。
