NucReg Research Programme, Molekylærbiologisk institutt, Unversitetet i Bergen, Thormøhlens gate 55, 5008, Bergen, Norway; Core Metabolomics and Lipidomics Laboratory, Department of Biochemistry, University of Cambridge, c/o Level 4, Pathology Building, Addenbrookes Hospital, Cambridge, CB2 0QQ, United Kingdom..
Faculty of Science, Engineering and Computing, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, United Kingdom.
Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jan;1863(1):9-19. doi: 10.1016/j.bbalip.2017.09.010. Epub 2017 Sep 28.
Successful passage through the cell cycle presents a number of structural challenges to the cell. Inceptive studies carried out in the last five years have produced clear evidence of modulations in the lipid profile (sometimes referred to as the lipidome) of eukaryotes as a function of the cell cycle. This mounting body of evidence indicates that lipids play key roles in the structural transformations seen across the cycle. The accumulation of this evidence coincides with a revolution in our understanding of how lipid composition regulates a plethora of biological processes ranging from protein activity through to cellular signalling and membrane compartmentalisation. In this review, we discuss evidence from biological, chemical and physical studies of the lipid fraction across the cell cycle that demonstrate that lipids are well-developed cellular components at the heart of the biological machinery responsible for managing progress through the cell cycle. Furthermore, we discuss the mechanisms by which this careful control is exercised.
细胞周期的顺利进行给细胞带来了许多结构上的挑战。在过去五年中进行的初步研究清楚地表明，真核生物的脂质谱（有时也称为脂质组）会随着细胞周期的变化而发生变化。越来越多的证据表明，脂质在整个周期中观察到的结构转变中起着关键作用。这一证据的积累与我们对脂质组成如何调节从蛋白质活性到细胞信号传导和膜区室化等众多生物学过程的理解的革命相吻合。在这篇综述中，我们讨论了细胞周期中脂质部分的生物学、化学和物理研究的证据，这些证据表明，脂质是生物机制的核心，是细胞内高度发达的组成部分，负责管理细胞周期的进程。此外，我们还讨论了这种精细控制的机制。
