Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA; Department of Physical Therapy & Athletic Training, University of Utah, Salt Lake City, UT, USA; Department of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA; Department of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA; Department of Biochemistry, University of Utah, Salt Lake City, UT, USA.
Curr Opin Cell Biol. 2020 Apr;63:162-173. doi: 10.1016/j.ceb.2020.01.006. Epub 2020 Feb 24.
The lipids that make up biological membranes tend to be the forgotten molecules of cell biology. The paucity of data on these important entities likely reflects the difficulties of studying and understanding their biological roles, rather than revealing a lack of importance. Indeed, the lipid composition of biological membranes has a profound impact on a diverse array of cellular processes. The focus of this review is on the effects of different lipid classes on the function of mitochondria, particularly bioenergetics, in health and disease.
构成生物膜的脂质往往是细胞生物学中被遗忘的分子。这些重要实体的数据缺乏可能反映了研究和理解其生物学作用的困难，而不是缺乏重要性。事实上，生物膜的脂质组成对多种细胞过程都有深远的影响。本综述的重点是不同脂质类别对线粒体功能（特别是生物能量学）在健康和疾病中的影响。
