Department of Neurosurgery, West China Hospital, Sichuan University, China.
Department of Neurosurgery, West China Hospital, Sichuan University, China.
Clin Chim Acta. 2017 Nov;474:155-158. doi: 10.1016/j.cca.2017.09.021. Epub 2017 Sep 28.
We conducted a meta-analysis to investigate the association between preoperative controlling nutritional status (CONUT) scores in various solid tumors and clinical outcomes.
Relevant studies published up to August 12, 2017 were identified using electronic databases, including PubMed, Embase, and Web of Science. The pooled hazard ratios (HR) and their corresponding 95% confidence intervals (CI) for overall survival (OS) and event-free survival (EFS) were calculated to explore the relationship between preoperative CONUT score and prognosis.
In total, 674 patients with solid tumors from four published studies were included in this meta-analysis. The pooled HR for OS was 1.98 (95% CI, 1.34-2.91, p=0.001), indicating that patients with high CONUT scores had worse OS. The pooled HR for EFS was 1.98 (95% CI, 1.34-2.93, p=0.001), revealing that high CONUT scores were significantly associated with short EFS.
Our data suggest that high preoperative CONUT scores indicate poor prognosis for patients with solid tumors. Further studies are needed to verify the significance of CONUT scores in clinical practice.
我们进行了一项荟萃分析，以调查各种实体瘤患者术前控制营养状况（CONUT）评分与临床结局之间的关系。
使用电子数据库（包括 PubMed、Embase 和 Web of Science）检索截至 2017 年 8 月 12 日发表的相关研究。计算总生存期（OS）和无事件生存期（EFS）的合并风险比（HR）及其相应的 95%置信区间（CI），以探讨术前 CONUT 评分与预后之间的关系。
共有来自四项已发表研究的 674 名实体瘤患者纳入本荟萃分析。OS 的合并 HR 为 1.98（95%CI，1.34-2.91，p=0.001），表明 CONUT 评分较高的患者 OS 较差。EFS 的合并 HR 为 1.98（95%CI，1.34-2.93，p=0.001），表明 CONUT 评分较高与 EFS 较短显著相关。
我们的数据表明，术前 CONUT 评分较高提示实体瘤患者预后不良。需要进一步的研究来验证 CONUT 评分在临床实践中的意义。
