Liu Rongqiang, Ji Lei, Zhang Chenxuan, Ye Jing, Li Xinyi, Ma Wangbin, Yu Jia, Wang Weixing
Department of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Front Nutr. 2025 Jun 30;12:1598463. doi: 10.3389/fnut.2025.1598463. eCollection 2025.
Numerous studies have highlighted the significance of controlling nutritional status (CONUT) score in the prognosis of patients with hepatocellular carcinoma (HCC). However, the precise role of the CONUT scor in predicting HCC prognosis remains unclear. This study aimed to investigate the prognostic significance of the CONUT scores in patients with HCC through an updated meta-analysis.
Three internationally recognized authoritative databases (PubMed, Web of Science and Embase) were searched. The research focused on the relationship between CONUT score and prognosis in patients with HCC. The deadline for literature search was October 23, 2024. In this study, hazard ratios (HRs) and odds ratios (ORs) were used as the primary statistical indicators for pooled analysis. All calculated HRs and ORs were accompanied by 95% confidence intervals (95% CIs). Data analyses were performed using STATA software, version 12.0.
A total of 19 relevant studies encompassing 7,963 patients were included in this meta-analysis. The CONUT score was significantly associated with unfavorable survival outcomes, including overall survival (OS) (HR: 1.58, 95% CI: 1.33-1.87), disease-free survival (DFS) (HR: 2.06, 95% CI: 1.34-3.18), recurrence-free survival (RFS) (HR: 1.48, 95% CI: 1.09-2.00), and progression-free survival (PFS) (HR: 1.93, 95% CI: 1.24-2.99). Subgroup analysis further confirmed the prognostic value of the CONUT score. Moreover, high CONUT score was strongly associated with tumor differentiation (poor vs. moderate/well) (OR: 1.32, 95% CI: 1.16-2.35) and tumor number (solitary vs. multiple) (OR: 1.25, 95% CI: 1.19-1.84).
HCC patients with high CONUT scores usually face a worse survival prognosis. The CONUT score may be a valid prognostic indicator for patients with HCC.
众多研究强调了控制营养状况（CONUT）评分在肝细胞癌（HCC）患者预后中的重要性。然而，CONUT评分在预测HCC预后的确切作用仍不清楚。本研究旨在通过一项更新的荟萃分析探讨CONUT评分在HCC患者中的预后意义。
检索了三个国际公认的权威数据库（PubMed、Web of Science和Embase）。该研究聚焦于CONUT评分与HCC患者预后之间的关系。文献检索截止日期为2024年10月23日。在本研究中，风险比（HRs）和比值比（ORs）用作汇总分析的主要统计指标。所有计算出的HRs和ORs均伴有95%置信区间（95% CIs）。使用STATA软件12.0版进行数据分析。
本荟萃分析共纳入19项相关研究，涉及7963例患者。CONUT评分与不良生存结局显著相关，包括总生存期（OS）（HR：1.58，95% CI：1.33 - 1.87）、无病生存期（DFS）（HR：2.06，95% CI：1.34 - 3.18）、无复发生存期（RFS）（HR：1.48，95% CI：1.09 - 2.00）和无进展生存期（PFS）（HR：1.93，95% CI：1.24 - 2.99）。亚组分析进一步证实了CONUT评分的预后价值。此外，高CONUT评分与肿瘤分化（差 vs. 中/好）（OR：1.32，95% CI：1.16 - 2.35）和肿瘤数量（单发 vs. 多发）（OR：1.25，95% CI：1.19 - 1.84）密切相关。
CONUT评分高的HCC患者通常面临更差的生存预后。CONUT评分可能是HCC患者有效的预后指标。
