Sentiss Research Centre, Sentiss Pharma, Gurgaon, Haryana 122001, India.
Department of Chemical Engineering, Texas Tech University, Lubbock, TX 79409, USA.
Drug Discov Today. 2018 May;23(5):1016-1025. doi: 10.1016/j.drudis.2017.09.013. Epub 2017 Sep 28.
Carbon nanomaterials have been attracting attention in oncology for the development of safe and effective cancer nanomedicines in increasing improved patient compliance for generally recognized as safe (GRAS) prominence. Toxicity, safety and efficacy of carbon nanomaterials are the major concerns in cancer theranostics. Various parameters such as particle size and shape or surface morphology, surface charge, composition, oxidation and nonoxidative-stress-related mechanisms are prone to toxicity of the carbon nanomaterials. Currently, few cancer-related products have been available on the market, although some are underway in preclinical and clinical phases. Thus, our main aim is to provide comprehensive details on the carbon nanomaterials in oncology from the past two decades for patient compliance and safety.
碳纳米材料在肿瘤学领域备受关注，因为它们可以开发出安全有效的癌症纳米药物，从而提高患者对一般认为安全（GRAS）药物的依从性。碳纳米材料的毒性、安全性和疗效是癌症治疗的主要关注点。各种参数，如颗粒大小和形状或表面形态、表面电荷、组成、氧化和非氧化应激相关机制，都容易导致碳纳米材料的毒性。目前，市场上只有少数与癌症相关的产品，尽管有些产品正处于临床前和临床阶段。因此，我们的主要目的是提供过去二十年中有关碳纳米材料在肿瘤学方面的综合信息，以提高患者的依从性和安全性。
