Huang Wei-Ling, Ma Yu-Xin, Fan Yu-Bao, Lai Sheng-Min, Liu Hong-Qing, Liu Jing, Luo Li, Li Guo-Ying, Tian Su-Min
Department of Anatomy, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, China.
Department of Physiology, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong Province, China.
Neural Regen Res. 2017 Aug;12(8):1287-1293. doi: 10.4103/1673-5374.213548.
Previous studies have demonstrated a neuroprotective effect of extract of against neuronal damage, but have mainly focused on antioxidation of extract of . To date, limited studies have determined whether extrasct of has a protective effect on neuronal damage. In the present study, acrylamide and 30, 60, and 120 mg/kg extract of were administered for 4 weeks by gavage to establish mouse models. Our results showed that 30, 60, and 120 mg/kg extract of effectively alleviated the abnormal gait of poisoned mice, and up-regulated protein expression levels of doublecortin (DCX), brain-derived neurotrophic factor, and growth associated protein-43 (GAP-43) in the hippocampus. Simultaneously, DCX- and GAP-43-immunoreactive cells increased. These findings suggest that extract of can mitigate neurotoxicity induced by acrylamide, and thereby promote neuronal regeneration in the hippocampus of acrylamide-treated mice.
先前的研究已经证明了[提取物名称]提取物对神经元损伤具有神经保护作用，但主要集中在[提取物名称]提取物的抗氧化作用上。迄今为止，关于[提取物名称]提取物是否对神经元损伤具有保护作用的研究有限。在本研究中，通过灌胃给予丙烯酰胺以及30、60和120mg/kg的[提取物名称]提取物，持续4周以建立小鼠模型。我们的结果表明，30、60和120mg/kg的[提取物名称]提取物有效缓解了中毒小鼠的异常步态，并上调了海马体中双皮质素（DCX）、脑源性神经营养因子和生长相关蛋白43（GAP-43）的蛋白表达水平。同时，DCX和GAP-43免疫反应性细胞增加。这些发现表明，[提取物名称]提取物可以减轻丙烯酰胺诱导的神经毒性，从而促进丙烯酰胺处理小鼠海马体中的神经元再生。
