Extract of promotes neuronal regeneration in the hippocampus after exposure to acrylamide.

Previous studies have demonstrated a neuroprotective effect of extract of against neuronal damage, but have mainly focused on antioxidation of extract of . To date, limited studies have determined whether extrasct of has a protective effect on neuronal damage. In the present study, acrylamide and 30, 60, and 120 mg/kg extract of were administered for 4 weeks by gavage to establish mouse models. Our results showed that 30, 60, and 120 mg/kg extract of effectively alleviated the abnormal gait of poisoned mice, and up-regulated protein expression levels of doublecortin (DCX), brain-derived neurotrophic factor, and growth associated protein-43 (GAP-43) in the hippocampus. Simultaneously, DCX- and GAP-43-immunoreactive cells increased. These findings suggest that extract of can mitigate neurotoxicity induced by acrylamide, and thereby promote neuronal regeneration in the hippocampus of acrylamide-treated mice.