银杏叶提取物EGb-761通过DDK1减轻氟化物对PC-12细胞的抗增殖活性。
EGb-761 Attenuates the Anti-proliferative Activity of Fluoride via DDK1 in PC-12 Cells.
作者信息
Zhang Cai-Yi, Chen Rui, Wang Fen, Ren Chao, Zhang Peng, Li Qian, Li Hui-Hua, Guo Ke-Tai, Geng De-Qin, Liu Chun-Feng
机构信息
Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Xuzhou Medical University Affiliated Xuzhou Oriental Hospital, No. 379 Tongshan Road, Xuzhou, 221000, Jiangsu Province, China.
出版信息
Neurochem Res. 2017 Feb;42(2):606-614. doi: 10.1007/s11064-016-2115-6. Epub 2016 Nov 25.
EGb-761 is commonly used as a treatment for ischemic brain injury, neurodegenerative diseases and some types of tumors (Christen and Maixent, in Cell Mol Biol 48(6):601-611, 2002). However, it is unclear whether EGb-761 affects the proliferation of cells exposed to fluoride. In this study, the proliferation and apoptosis of PC-12 cells exposed to fluoride were investigated and EGb-761 was used to protect PC-12 cells against the effects of fluoride. We found that the canonical Wnt signaling pathway was involved in the anti-proliferation of PC-12 cells exposed to fluoride. Furthermore, the results also showed that EGb-761 could attenuate the anti-proliferative activity of fluoride via DDK1 in PC-12 cells. This study may provide a new method for protecting against the inhibition of cell proliferation induced by fluoride.
EGb - 761通常被用作缺血性脑损伤、神经退行性疾病和某些类型肿瘤的治疗药物（克里斯汀和迈克森特，发表于《细胞与分子生物学》48(6):601 - 611，2002年）。然而，尚不清楚EGb - 761是否会影响暴露于氟化物的细胞的增殖。在本研究中，我们研究了暴露于氟化物的PC - 12细胞的增殖和凋亡情况，并使用EGb - 761来保护PC - 12细胞免受氟化物的影响。我们发现，经典的Wnt信号通路参与了暴露于氟化物的PC - 12细胞的抗增殖过程。此外，结果还表明，EGb - 761可以通过DDK1减弱氟化物在PC - 12细胞中的抗增殖活性。本研究可能为预防氟化物诱导的细胞增殖抑制提供一种新方法。
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