Peng Sheng, Shen Ting, Liu Jie, Tomlinson Brian, Sun Huimin, Chen Xiaoli, Chan Paul, Kuang YaShu, Zheng Liang, Wu Hong, Ding Xugang, Qian Dingguang, Shen Yixin, Gao Pingjin, Fan Huimin, Liu Zhongmin, Zhang Yuzhen
1Key Laboratory of Arrhythmias, Ministry of Education, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
2Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Aging Dis. 2017 Oct 1;8(5):558-569. doi: 10.14336/AD.2016.1220. eCollection 2017 Oct.
We determined the prevalence of hypertension, medication usage and attainment of blood pressure goals in older (≥65 to <80 years and ≥80 years) urban community-dwelling Chinese subjects. Data were obtained in 3950 subjects (mean age 72.0 years, 1745 male) including 609 subjects aged ≥80 years in the Shanghai Elderly Cardiovascular Health Study (SHECHS). Established cardiovascular disease was present in 7.7% of participants. The prevalence of hypertension was 74.8% overall and it was more than 80% in individuals considered to be in moderate and higher cardiovascular disease risk categories. In hypertensive subjects, 67.1% were on treatment and treatment was more frequent in high and very high cardiovascular risk individuals. Attainment of the systolic blood pressure goal <150 mmHg was 62.9% and was greater in the ≥65 to <80 years group than in the ≥80 years group. The most commonly used antihypertensive treatments were calcium channel blockers (54.2%), followed by angiotensin receptor blockers (43.1%). Diuretics were used in 2.6%. Fixed-dose combination antihypertensive tablets were used in some of the ≥65 to <80 years group (12.4%) and more of the ≥80 years group (18.2%) and 70.9% of the ≥65 to <80 years group and 80.2% of the ≥80 years group were on monotherapy. There were high prevalence and high treatment rates of hypertension, but poor attainment of the systolic blood pressure goal of <150 mmHg, especially in the ≥80 years group of community-dwelling Chinese. Considering that more intensive treatment of hypertension in older subjects may be warranted after recent studies, this might be achieved by more frequent use of combinations of effective therapies and diuretics.
我们确定了年龄较大(≥65至<80岁以及≥80岁)的城市社区居住中国受试者中高血压的患病率、药物使用情况以及血压目标的达成情况。在上海老年心血管健康研究(SHECHS)中,对3950名受试者(平均年龄72.0岁,男性1745名)进行了数据采集,其中包括609名年龄≥80岁的受试者。7.7%的参与者存在已确诊的心血管疾病。高血压的总体患病率为74.8%,在被认为心血管疾病风险处于中度及更高水平的个体中,患病率超过80%。在高血压患者中,67.1%正在接受治疗,且在心血管疾病高风险和极高风险个体中治疗更为频繁。收缩压目标<150 mmHg的达成率为62.9%,≥65至<80岁组高于≥80岁组。最常用的降压治疗药物是钙通道阻滞剂(54.2%),其次是血管紧张素受体阻滞剂(43.1%)。利尿剂的使用率为2.6%。≥65至<80岁组的部分患者(12.4%)以及≥80岁组的更多患者(18.2%)使用了固定剂量复方降压片,≥65至<80岁组的70.9%以及≥80岁组的80.2%采用单药治疗。高血压的患病率和治疗率都很高,但收缩压目标<150 mmHg的达成情况较差,尤其是在社区居住的≥80岁中国人群体中。鉴于近期研究表明可能需要对老年受试者进行更强化的高血压治疗,这或许可以通过更频繁地使用有效治疗药物和利尿剂的联合治疗来实现。