人类卵母细胞的卵质移植：辅助生殖中的疗效与问题
Ooplasmic transfer in human oocytes: efficacy and concerns in assisted reproduction.
作者信息
Darbandi Sara, Darbandi Mahsa, Khorram Khorshid Hamid Reza, Sadeghi Mohammad Reza, Agarwal Ashok, Sengupta Pallav, Al-Hasani Safaa, Akhondi Mohammad Mehdi
机构信息
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
出版信息
Reprod Biol Endocrinol. 2017 Oct 2;15(1):77. doi: 10.1186/s12958-017-0292-z.
BACKGROUND
Ooplasmic transfer (OT) technique or cytoplasmic transfer is an emerging technique with relative success, having a significant status in assisted reproduction. This technique had effectively paved the way to about 30 healthy births worldwide. Though OT has long been invented, proper evaluation of the efficacy and risks associated with this critical technique has not been explored properly until today. This review thereby put emphasis upon the applications, efficacy and adverse effects of OT techniques in human.
MAIN BODY
Available reports published between January 1982 and August 2017 has been reviewed and the impact of OT on assisted reproduction was evaluated. The results consisted of an update on the efficacy and concerns of OT, the debate on mitochondrial heteroplasmy, apoptosis, and risk of genetic and epigenetic alteration.
SHORT CONCLUSION
The application of OT technique in humans demands more clarity and further development of this technique may successfully prove its utility as an effective treatment for oocyte incompetence.
背景
卵质移植（OT）技术或细胞质移植是一项取得了相对成功的新兴技术，在辅助生殖领域具有重要地位。该技术已在全球范围内有效地促成了约30例健康婴儿的诞生。尽管卵质移植技术早已问世，但直至今日，仍未对这一关键技术的疗效和风险进行恰当评估。因此，本综述着重探讨了卵质移植技术在人类中的应用、疗效及不良反应。
正文
对1982年1月至2017年8月间发表的现有报告进行了综述，并评估了卵质移植对辅助生殖的影响。结果包括对卵质移植疗效和相关问题的更新、关于线粒体异质性、细胞凋亡以及遗传和表观遗传改变风险的争论。
简短结论
卵质移植技术在人类中的应用需要更清晰的认识，该技术的进一步发展可能成功证明其作为治疗卵母细胞功能不全的有效方法的效用。
Zotero 插件