National Biopesticide Engineering Technology Research Center, Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Mini Rev Med Chem. 2018;18(9):745-775. doi: 10.2174/1389557517666171003103245.
Steroid and its derivatives have been proved to have important and diverse biological functions, which present the wide spectrum of biological activities such as antitumor, antiviral, antibacterial, antimicrobial, antifungal, antioxidant, insecticidal, aromatase inhibitors, 5α-reductase inhibitors and neuromuscular blocking agents etc. Versatile features of steroid-derived compounds have emerged, so the aim of the present paper is to review the recent advances of steroid-based derivatives mainly focused on their structures and biological applications, which can be employed for further development to discover potential drug candidates.
甾体及其衍生物已被证明具有重要且多样的生物学功能，呈现出广泛的生物活性，如抗肿瘤、抗病毒、抗菌、抗微生物、抗真菌、抗氧化、杀虫、芳香酶抑制剂、5α-还原酶抑制剂和神经肌肉阻滞剂等。甾体衍生化合物的多功能特性已经显现，因此本文旨在综述基于甾体的衍生物的最新进展，主要关注其结构和生物应用，这可用于进一步开发以发现潜在的药物候选物。
