顶孢霉属真菌的次生代谢产物：多样的结构与生物活性。

Secondary Metabolites from Acremonium Fungi: Diverse Structures and Bioactivities.

作者信息

Tian Jin, Lai Daowan, Zhou Ligang

机构信息

Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, China.

Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, India.

出版信息

Mini Rev Med Chem. 2017;17(7):603-632. doi: 10.2174/1389557516666160914194134.

DOI:10.2174/1389557516666160914194134

PMID:27633747

Abstract

BACKGROUND

Acremonium fungi have been isolated from various sources, such as soil, plants, and marine organisms.

METHOD

The species in Acremonium have been proved to be rich sources of novel and bioactive secondary metabolites. Up to now, 356 metabolites belonging to steroids (6 compounds), terpenoids (86), meroterpenoids (66), polyketides (89), alkaloids (28), peptides (75), and miscellaneous types (6) have been isolated from Acremonium fungi. These metabolites displayed a wide range of biological activities including antimicrobial, cytotoxic, antitumor, immunosuppressive, antioxidant, antiinflammatory, antimalarial, phytotoxic, tremorgenic, antiviral, neuritogenic, insecticidal and enzymesinhibiting activities.

CONCLUSION

This review highlights the structures and bioactivities of the secondary metabolites from Acremonium fungi reported until July 2016.

摘要

背景

枝顶孢属真菌已从各种来源中分离出来，如土壤、植物和海洋生物。

方法

已证明枝顶孢属中的物种是新型生物活性次级代谢产物的丰富来源。截至目前，已从枝顶孢属真菌中分离出356种代谢产物，分别属于甾体（6种化合物）、萜类化合物（86种）、杂萜类化合物（66种）、聚酮类化合物（89种）、生物碱（28种）、肽类（75种）和其他类型（6种）。这些代谢产物表现出广泛的生物活性，包括抗菌、细胞毒性、抗肿瘤、免疫抑制、抗氧化、抗炎、抗疟疾、植物毒性、震颤性、抗病毒、促神经生成、杀虫和酶抑制活性。