N.N. Blokhin National Medical Research Center of Oncology, Kashirskoe shosse, 24, 115478 Moscow, Russia.
N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia.
Mar Drugs. 2018 Sep 13;16(9):333. doi: 10.3390/md16090333.
Immunosuppression derived after cytostatics application in cancer chemotherapy is considered as an adverse side effect that leads to deterioration of quality of life and risk of infectious diseases. A linear sulfated (1→3)-α-l-fucan prepared by chemical modification of a fucoidan isolated from the brown seaweed , along with two structurally related synthetic sulfated oligosaccharides, were studied as stimulators of hematopoiesis on a model of cyclophosphamide immunosuppression in mice. Recombinant granulocyte colony-stimulating factor (), which is currently applied in medicine to treat low blood neutrophils, was used as a reference. Polysaccharide and sulfated difucoside did not demonstrate significant effect, while sulfated octasaccharide showed higher activity than , causing pronounced neutropoiesis stimulation. In addition, production of erythrocytes and platelets was enhanced after the octasaccharide administration. The assessment of populations of cells in blood and bone marrow of mice revealed the difference in mechanisms of action of and .
癌症化疗中应用细胞抑制剂后产生的免疫抑制被认为是一种不良的副作用，会导致生活质量恶化和传染病风险增加。一种通过化学修饰从褐藻中分离得到的岩藻聚糖制备的线性硫酸化（1→3）-α-L-岩藻聚糖，以及两种结构上相关的合成硫酸化寡糖，被用作环磷酰胺免疫抑制小鼠模型中造血刺激剂进行研究。目前用于治疗血液中中性粒细胞减少的重组粒细胞集落刺激因子 ( ) 被用作参考。多糖 和硫酸化二岩藻寡糖 没有表现出显著的效果，而硫酸化八岩藻寡糖 表现出比 更高的活性，导致明显的嗜中性粒细胞刺激作用。此外，八岩藻寡糖给药后还能增强红细胞和血小板的产生。对小鼠血液和骨髓细胞群的评估揭示了 和 作用机制的差异。
