Jahic Mahira, Jahic Elmir, Mulavdic Mirsada, Hadzimehmedovic Azra
Private Gynecology Ordination, Dr Mahira Jahic" Tuzla, Tuzla, Bosnia and Herzegovina.
University of Tuzla, Faculty of Medicine Tuzla, Tuzla, Tuzla, Bosnia and Herzegovina.
Med Arch. 2017 Aug;71(4):280-283. doi: 10.5455/medarh.2017.71.280-283.
Cervical cancer can be successfully prevented by effective treatment.
Analyse of success of cryotherapy in LSIL and ASCUS.
In retrospective study between January 2016 to March 2017, 3244 PAP test were analysed. 257 patients who had been diagnosed with LSIL and ASCUS from PAP smear were divided in two groups: women who had HPV positive, colposcopic positive and cytologic finding of LSIL or ASCUS treathed with cryotherapy and women with LSIL, ASCUS and negative colposcopy. χ test was used for statistical analysis of data.
Analysis of 3244 PAP smears showed negative for intraepithelial lesion or malignancy (NILM) in 90,10% (N-2923), and abnormal in 9,8% (N-321) of women. ASCUS was found in 4,8% (N-156) and ASC-H in 0,2% (N-6), LSIL in 3,1% (N-101), HSIL in 0,64% (N-21). The average age of patients with ASCUS lesion was 41 ± 12 years. After cryotherapy, HSIL had progression in 1,5% (N-1), persistence in 6,3% (N-4) and regression in 91,7% (N-58). Progression occured in 10,5% (N-4) of HSIL, persistence in 52,6% (N-20) and regression in 36,7% (N-14) in 38 women with LSIL lesion after repeated PAP test. Progression occured in 8% (N-10) of LSIL and 4% HSIL (N-5), persistence in 58% (N-72) and regression in 29,8% (N-37) in 124 women with ASCUS lesion after treatment and repeated PAP test. Difference in progression lesions in HSIL between women with cryotherapy (1,5%) and follow-up (10,5%) after LSIL is not significant, but progression to CIN II occured after cryotherapy. CIN III or cervical cancer was not found.
Cryotherapy prevents progression of LSIL in HSIL and in cervical cancer. Because of that cryotherapy is successful method in prevention of cervical cancer.
宫颈癌可通过有效治疗成功预防。
分析冷冻疗法对低度鳞状上皮内病变（LSIL）和非典型鳞状细胞不能明确意义（ASCUS）的治疗效果。
回顾性研究2016年1月至2017年3月期间的3244例巴氏试验。257例经巴氏涂片诊断为LSIL和ASCUS的患者分为两组：HPV阳性、阴道镜检查阳性且细胞学检查为LSIL或ASCUS并接受冷冻治疗的女性，以及LSIL、ASCUS且阴道镜检查阴性的女性。采用χ检验对数据进行统计学分析。
对3244例巴氏涂片分析显示，90.10%（N = 2923）的女性上皮内病变或恶性肿瘤检查结果为阴性（NILM），9.8%（N = 321）的女性检查结果异常。4.8%（N = 156）的女性发现有ASCUS，0.2%（N = 6）的女性发现有非典型鳞状细胞不除外高度病变（ASC-H），3.1%（N = 101）的女性发现有LSIL，0.64%（N = 21）的女性发现有高度鳞状上皮内病变（HSIL）。ASCUS病变患者的平均年龄为41±12岁。冷冻治疗后，HSIL进展的比例为1.5%（N = 1），持续的比例为6.3%（N = 4），消退的比例为91.7%（N = 58）。38例LSIL病变女性经重复巴氏试验后，HSIL进展的比例为10.5%（N = 4），持续的比例为52.6%（N = 20），消退的比例为36.7%（N = 14）。124例ASCUS病变女性治疗及重复巴氏试验后，LSIL进展的比例为8%（N = 10），HSIL进展的比例为4%（N = 5），持续的比例为58%（N = 72），消退的比例为29.8%（N = 37）。冷冻治疗组（1.5%）与随访组（10.5%）的HSIL病变进展差异无统计学意义，但冷冻治疗后出现了进展为CIN II的情况。未发现CIN III或宫颈癌。
冷冻疗法可预防HSIL中LSIL的进展及宫颈癌的发生。因此，冷冻疗法是预防宫颈癌的成功方法。
