Costa Weruska Alcoforado, Eleutério José, Giraldo Paulo César, Gonçalves Ana Katherine
Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil.
Rev Assoc Med Bras (1992). 2017 Jul;63(7):583-589. doi: 10.1590/1806-9282.63.07.583.
To evaluate the influence of functional capacity (FC) and how it affects quality of life (QoL) in breast cancer survivors.
A total of 400 breast cancer survivors were studied - 118 without metastasis, 160 with locoregional metastasis and 122 with distant metastasis. The European Organization for Research and Treatment for Cancer Quality of Life Questionnaire--Core 30 (EORTC QLQ-C30), Breast Cancer-Specific (EORTC QLQ-BR23), and the Karnofsky Performance Scale (KPS) were used to evaluate FC and QoL.
Women with distant metastases presented lower KPS 75.3 (SD=12.5) (p<0.001). For QLQ-C30, the mean of the Functional Scale for patients with distant metastasis was 57 (SD=19) (p<0.001), and the mean of the Symptom Scale for patients with distant metastasis was 37 (SD=20) (p<0.001). Both the scales for pain and fatigue showed the highest mean in the groups. For the Global Health Scale, patients without metastasis scored a mean of 62 (SD=24) points, while those with locoregional metastases scored a mean of 63 (SD=21.4), and distant metastasis scored 51.3 (SD=24) points. In the group with distant metastases, 105 (87%) had pain, and the average KPS was 74 (SD=12.0) (p=0.001).
Breast cancer was associated with decreased FC, compromised QoL in women with locoregional and distant metastases compared to those without metastasis.
评估功能能力（FC）对乳腺癌幸存者生活质量（QoL）的影响及其作用方式。
共研究了400名乳腺癌幸存者，其中118例无转移，160例有局部区域转移，122例有远处转移。采用欧洲癌症研究与治疗组织生活质量问卷核心30项（EORTC QLQ-C30）、乳腺癌特异性问卷（EORTC QLQ-BR23）和卡氏功能状态量表（KPS）评估FC和QoL。
有远处转移的女性KPS评分较低，为75.3（标准差=12.5）（p<0.001）。对于QLQ-C30，远处转移患者功能量表的平均分为57（标准差=19）（p<0.001），症状量表的平均分为37（标准差=20）（p<0.001）。疼痛和疲劳量表在各亚组中的平均分最高。在总体健康量表方面，无转移患者的平均得分为62（标准差=24）分，局部区域转移患者为63（标准差=21.4）分，远处转移患者为51.3（标准差=24）分。在远处转移组中，105例（87%）有疼痛，平均KPS评分为74（标准差=12.0）（p=0.001）。
与无转移的女性相比，乳腺癌与功能能力下降以及局部区域和远处转移女性的生活质量受损有关。
