Golpe Rafael, Martín-Robles Irene, Sanjuán-López Pilar, Pérez-de-Llano Luis, González-Juanatey Carlos, López-Campos José L, Arellano-Orden Elena
Respiratory Medicine Service.
Cardiology Service, University Hospital Lucus Augusti, Lugo.
Int J Chron Obstruct Pulmon Dis. 2017 Sep 1;12:2639-2646. doi: 10.2147/COPD.S141068. eCollection 2017.
It is known that biomarkers of systemic inflammation are raised in COPD caused by tobacco (T-COPD) compared with healthy controls, but there is less information on the inflammatory status of subjects with COPD caused by biomass smoke (B-COPD). In addition, the possible (if any) differences in inflammation between both types of the disease are still not well known. The aim of this study was to assess the inflammatory profile in B-COPD and T-COPD.
A total of 20 subjects (15 men and five women) with T-COPD were matched one to one for sex, age and forced expiratory volume in 1 s (FEV) to 20 B-COPD patients. In all, 20 sex-matched healthy subjects with normal lung function without smoking history or biomass exposure were included as controls. The following biomarkers were measured: exhaled nitric oxide, serum IL-6, IL-8, IL-5, IL-13, periostin, surfactant protein-P, TNF-α, IgE, erythrocyte sedimentation rate, C-reactive protein and fibrinogen. Complete blood count was also obtained.
The age of the subjects was 70.2±7.9 years and FEV% was 56.2%±14.6%. Most inflammatory biomarkers were higher in both types of COPD than in healthy controls. IL-6, IL-8 and IL-5 were significantly higher in T-COPD than in B-COPD, without other significant differences.
Both types of COPD are associated with high levels of systemic inflammation biomarkers. T-COPD patients have a higher systemic inflammatory status than the patients with B-COPD.
已知与健康对照相比，烟草所致慢性阻塞性肺疾病（T-COPD）患者的全身炎症生物标志物水平升高，但关于生物质烟雾所致慢性阻塞性肺疾病（B-COPD）患者的炎症状态信息较少。此外，两种类型疾病之间炎症方面可能存在的差异（若有）仍不清楚。本研究的目的是评估B-COPD和T-COPD患者的炎症特征。
20例T-COPD患者（15例男性和5例女性）按照性别、年龄和第1秒用力呼气容积（FEV）与20例B-COPD患者进行一对一匹配。另外，纳入20例性别匹配、肺功能正常、无吸烟史或生物质暴露史的健康受试者作为对照。检测以下生物标志物：呼出一氧化氮、血清白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、白细胞介素-5（IL-5）、白细胞介素-13（IL-13）、骨膜蛋白、表面活性蛋白-P、肿瘤坏死因子-α（TNF-α）、免疫球蛋白E（IgE）、红细胞沉降率、C反应蛋白和纤维蛋白原。同时进行全血细胞计数。
受试者年龄为70.2±7.9岁，FEV%为56.2%±14.6%。两种类型的COPD患者大多数炎症生物标志物水平均高于健康对照。T-COPD患者的IL-6、IL-8和IL-5水平显著高于B-COPD患者，其他方面无显著差异。
两种类型的COPD均与全身炎症生物标志物水平升高有关。T-COPD患者的全身炎症状态高于B-COPD患者。
