热休克蛋白27（HSP27）在胃癌中的临床病理意义：一项荟萃分析
Clinicopathological significance of HSP27 in gastric cancer: a meta-analysis.
作者信息
Ge Hua, He Xueyan, Guo Lingfei, Yang Xianzhi
机构信息
Department of Gastrointestinal Surgery, The First People's Hospital of Zunyi, Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.
出版信息
Onco Targets Ther. 2017 Sep 13;10:4543-4551. doi: 10.2147/OTT.S146590. eCollection 2017.
BACKGROUND
Many studies have provided increasing evidence to demonstrate that HSP27 has been involved in the development of gastric cancer; however, they all include few patients and the results remain controversial. Hence, we conducted a meta-analysis to evaluate correlations between HSP27 and the clinicopathological characteristics of gastric cancer.
METHODS
An electronic search for relevant articles was conducted in PubMed, Cochrane Library, Web of Science, EMBASE database, Chinese CNKI, and Wan Fang. Data on the relationship between HSP27 expression and lymph node metastasis, serosal invasion, gender, tumor size, differentiation, and TNM stage were extracted. Pooled odds ratios and 95% confidence intervals were estimated by forest plot.
RESULTS
The pooled analyses suggested that HSP27 expression was significantly associated with the incidence of gastric cancer. However, HSP27 expression had no significant relationship with lymph node metastasis, serosal invasion, gender, tumor size, differentiation, and TNM stage.
CONCLUSION
Our meta-analysis demonstrated that HSP27 may play vital roles in tumorigenesis and deterioration of gastric cancer. However, further high-quality studies are needed to provide more reliable evidence.
背景
许多研究提供了越来越多的证据表明热休克蛋白27（HSP27）参与了胃癌的发生发展；然而，这些研究纳入的患者均较少，结果仍存在争议。因此，我们进行了一项荟萃分析，以评估HSP27与胃癌临床病理特征之间的相关性。
方法
在PubMed、Cochrane图书馆、科学网、EMBASE数据库、中国知网和万方数据库中进行电子检索，查找相关文章。提取HSP27表达与淋巴结转移、浆膜侵犯、性别、肿瘤大小、分化程度及TNM分期之间关系的数据。通过森林图估计合并比值比和95%置信区间。
结果
汇总分析表明，HSP27表达与胃癌的发生率显著相关。然而，HSP27表达与淋巴结转移、浆膜侵犯、性别、肿瘤大小、分化程度及TNM分期均无显著关系。
结论
我们的荟萃分析表明，HSP27可能在胃癌的发生和恶化过程中发挥重要作用。然而，需要进一步开展高质量研究以提供更可靠的证据。
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