Liu Tong, Liu Duo, Kong Xiangxue, Dong Mei
Harbin Medical University Cancer Hospital, Harbin, China.
Evid Based Complement Alternat Med. 2020 Jul 22;2020:7018562. doi: 10.1155/2020/7018562. eCollection 2020.
HSP27 is a protein chaperone protecting cell from heat shock, and upregulated HSP27 expression has been found in many different cancers. We conduct this update meta-analysis to evaluate the relationship between HSP27 expression and clinicopathological features.
We searched PubMed, Chinese CNKI, and WanFang databases to identify studies that assessed the association between clinicopathological feature and HSP27 expression in gastric cancer patients.
We found overexpression of HSP27 was associated with incidence of gastric cancer (OR = 6.31, 95% CI = 1.10-36.15, < 0.0001). However, there was no significant difference between HSP27 expression and gastric cancer differentiation, gender difference, lymph node metastasis, and distant metastasis.
Our meta-analysis study indicates that overexpression of HSP27 is associated with incidence of gastric cancer statistically.
热休克蛋白27(HSP27)是一种保护细胞免受热休克的蛋白质伴侣,在许多不同癌症中均发现HSP27表达上调。我们进行此项更新的荟萃分析以评估HSP27表达与临床病理特征之间的关系。
我们检索了PubMed、中国知网(CNKI)和万方数据库,以识别评估胃癌患者临床病理特征与HSP27表达之间关联的研究。
我们发现HSP27过表达与胃癌发病率相关(比值比[OR]=6.31,95%置信区间[CI]=1.10-36.15,P<0.0001)。然而,HSP27表达与胃癌分化、性别差异、淋巴结转移和远处转移之间无显著差异。
我们的荟萃分析研究表明,HSP27过表达在统计学上与胃癌发病率相关。