Javadi Seyed Alireza Haji Seyed, Shafikhani Ali Akbar
MD of Psychiatry, Assistant Professor, Department of Psychiatry, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
MSc. in Occupational Health Engineering, Department of Occupational Health, Faculty of Health, Qazvin University of Medical Sciences, Qazvin, Iran.
Electron Physician. 2017 Aug 1;9(8):5107-5112. doi: 10.19082/5107. eCollection 2017 Aug.
Evidence shows an influence relationship between described symptoms of gastroesophageal reflux disorder (GERD) and emotional state.
To determine the relationship between anxiety and depression with GERD in patients referred to the endoscopy unit of Bouali-Sina Hospital in Qazvin.
This case-control study was conducted in the endoscopy unit of Bouali-Sina Hospital in Qazvin, Iran, from April 2014 through May 2015. Two hundred individuals (100 patients with GERD and 100 healthy individuals as a control group) were enrolled into the current study. All subjects completed the hospital anxiety and depression questionnaire. GERD was diagnosed based on the Los Angeles classification system. Demographic and socioeconomic characteristics in addition to clinical history of subjects were collected and analyzed using proper statistical methods (independent-samples t-test and AVOVA) and using SPSS version 22.
Among the recruited patients, 50 subjects had erosive esophagitis (ERD) and 50 had non-erosive esophagitis (NERD). The anxiety score was significantly higher in the NERD group than the ERD and control groups (p=0.017; p<0.001). In addition, the anxiety score was significantly higher in the ERD group than the control group (p=0.014). The score of depression was higher in the NERD group than the ERD and the control groups. However, this difference was not statistically significant for the ERD group (p=0.63), but the difference was significant in comparison to the control group (p<0.001). There was no significant difference among the groups regarding age, gender or body mass index (BMI). The number of smokers was significantly higher in the ERD group than the NERD and control groups (p<0.001).
The current study showed that mental factors (anxiety and depression) play important roles in the development of GERD, especially NERD; therefore, it is recommended to consider these factors to select a suitable treatment plan.
有证据表明胃食管反流病（GERD）的症状与情绪状态之间存在影响关系。
确定加兹温市布阿利 - 西纳医院内镜科就诊患者中焦虑、抑郁与GERD之间的关系。
本病例对照研究于2014年4月至2015年5月在伊朗加兹温市布阿利 - 西纳医院内镜科进行。招募了200名个体（100名GERD患者和100名健康个体作为对照组）纳入本研究。所有受试者均完成医院焦虑抑郁问卷。GERD根据洛杉矶分类系统进行诊断。收集受试者的人口统计学和社会经济特征以及临床病史，并使用适当的统计方法（独立样本t检验和方差分析）和SPSS 22版进行分析。
在招募的患者中，50名受试者患有糜烂性食管炎（ERD），50名患有非糜烂性食管炎（NERD）。NERD组的焦虑评分显著高于ERD组和对照组（p = 0.017；p < 0.001）。此外，ERD组的焦虑评分显著高于对照组（p = 0.014）。NERD组的抑郁评分高于ERD组和对照组。然而，ERD组的这种差异无统计学意义（p = 0.63），但与对照组相比差异显著（p < 0.001）。各组在年龄、性别或体重指数（BMI）方面无显著差异。ERD组的吸烟者数量显著高于NERD组和对照组（p < 0.001）。
本研究表明心理因素（焦虑和抑郁）在GERD尤其是NERD的发生发展中起重要作用；因此，建议在选择合适的治疗方案时考虑这些因素。
