假转录及其对细胞功能的影响。
Spurious transcription and its impact on cell function.
作者信息
Wade Joseph T, Grainger David C
机构信息
a Wadsworth Center , New York State Department of Health , Albany , NY , USA.
b Department of Biomedical Sciences , School of Public Health, University at Albany, SUNY , Albany , NY , USA.
出版信息
Transcription. 2018;9(3):182-189. doi: 10.1080/21541264.2017.1381794. Epub 2017 Nov 3.
Abstract
Most RNA polymerases can initiate transcription from diverse DNA template sequences with relatively few outright sequence restraints. Recent reports have demonstrated that failure to subdue the promiscuity of RNA polymerase in vivo can severely impede cell function. This phenomenon appears common to all cell types with undesirable effects ranging from growth inhibition in prokaryotes to cancer in higher organisms. Here we discuss similarities and differences in strategies employed by cells to minimise spurious transcription across life's domains.
摘要
大多数RNA聚合酶能够从多种DNA模板序列起始转录，对序列的直接限制相对较少。最近的报道表明，在体内未能抑制RNA聚合酶的杂乱性会严重阻碍细胞功能。这种现象在所有细胞类型中似乎都很常见，其不良影响范围从原核生物中的生长抑制到高等生物中的癌症。在这里，我们讨论了不同生命域的细胞为尽量减少错误转录而采用的策略的异同。
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