一个聚尿苷酸聚合酶家族。
A family of poly(U) polymerases.
作者信息
Kwak Jae Eun, Wickens Marvin
机构信息
Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
出版信息
RNA. 2007 Jun;13(6):860-7. doi: 10.1261/rna.514007. Epub 2007 Apr 20.
Abstract
The GLD-2 family of poly(A) polymerases add successive AMP monomers to the 3' end of specific RNAs, forming a poly(A) tail. Here, we identify a new group of GLD-2-related nucleotidyl transferases from Arabidopsis, Schizosaccharomyces pombe, Caenorhabditis elegans, and humans. Like GLD-2, these enzymes are template independent and add nucleotides to the 3' end of an RNA substrate. However, these new enzymes, which we refer to as poly(U) polymerases, add poly(U) rather than poly(A) to their RNA substrates.
摘要
聚腺苷酸聚合酶的GLD-2家族将连续的AMP单体添加到特定RNA的3'末端，形成聚腺苷酸尾。在此，我们从拟南芥、粟酒裂殖酵母、秀丽隐杆线虫和人类中鉴定出一组新的与GLD-2相关的核苷酸转移酶。与GLD-2一样，这些酶不依赖模板，并将核苷酸添加到RNA底物的3'末端。然而，这些我们称为聚尿苷酸聚合酶的新酶，会向其RNA底物添加聚尿苷酸而非聚腺苷酸。
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