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Fine-tuning PERK signaling to control cell fate under stress.

作者信息

Urra Hery, Hetz Claudio

机构信息

Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile, the Center for Geroscience, Brain Health and Metabolism, Santiago, Chile, and the Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.

Buck Institute for Research in Aging, Novato, California, USA and in the Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.

出版信息

Nat Struct Mol Biol. 2017 Oct 5;24(10):789-790. doi: 10.1038/nsmb.3478.

DOI:10.1038/nsmb.3478
PMID:28981072
Abstract
摘要

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CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response.CNPY2是未折叠蛋白反应的PERK-CHOP信号通路的关键启动因子。
Nat Struct Mol Biol. 2017 Oct;24(10):834-839. doi: 10.1038/nsmb.3458. Epub 2017 Sep 4.
2
CNPY2 promoted the proliferation of renal cell carcinoma cells and increased the expression of TP53.CNPY2促进肾癌细胞增殖并增加TP53的表达。
Biochem Biophys Res Commun. 2017 Apr 1;485(2):267-271. doi: 10.1016/j.bbrc.2017.02.095. Epub 2017 Feb 21.
3
Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway.
CNPY2 在动脉粥样硬化进程中内皮损伤和炎症中的作用。
J Mol Histol. 2023 Jun;54(3):195-205. doi: 10.1007/s10735-023-10122-z. Epub 2023 Apr 27.
4
Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cerebral Ischemia/Reperfusion Injury.内质网应激与脑缺血/再灌注损伤中的未折叠蛋白反应
Front Cell Neurosci. 2022 May 4;16:864426. doi: 10.3389/fncel.2022.864426. eCollection 2022.
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Thapsigargin: key to new host-directed coronavirus antivirals?他普司他汀:新型靶向宿主冠状病毒抗病毒药物的关键?
Trends Pharmacol Sci. 2022 Jul;43(7):557-568. doi: 10.1016/j.tips.2022.04.004. Epub 2022 Apr 18.
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Multi-level inhibition of coronavirus replication by chemical ER stress.化学内质网应激对冠状病毒复制的多层次抑制作用。
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Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway.黄连素通过下调CNPY2信号通路减轻脑缺血再灌注损伤诱导的神经元凋亡。
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Eur Heart J. 2015 Oct 1;36(37):2530-40. doi: 10.1093/eurheartj/ehv294. Epub 2015 Jul 9.
6
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