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滴吸法中的毒物形成:萜烯的故事

Toxicant Formation in Dabbing: The Terpene Story.

作者信息

Meehan-Atrash Jiries, Luo Wentai, Strongin Robert M

机构信息

Department of Chemistry, Portland State University, 1719 SW 10th Avenue, Portland, Oregon 97201, United States.

出版信息

ACS Omega. 2017 Sep 30;2(9):6112-6117. doi: 10.1021/acsomega.7b01130. Epub 2017 Sep 22.

Abstract

Inhalable, noncombustible cannabis products are playing a central role in the expansion of the medical and recreational use of cannabis. In particular, the practice of "dabbing" with butane hash oil has emerged with great popularity in states that have legalized cannabis. Despite their growing popularity, the degradation product profiles of these new products have not been extensively investigated. The study herein focuses on the chemistry of myrcene and other common terpenes found in cannabis extracts. Methacrolein, benzene, and several other products of concern to human health were formed under the conditions that simulated real-world dabbing. The terpene degradation products observed are consistent with those reported in the atmospheric chemistry literature.

摘要

可吸入的、不可燃的大麻产品在大麻医疗和娱乐用途的扩展中发挥着核心作用。特别是,使用丁烷大麻脂进行“滴吸”的做法在大麻合法化的州非常流行。尽管这些新产品越来越受欢迎,但它们的降解产物谱尚未得到广泛研究。本文的研究重点是大麻提取物中月桂烯和其他常见萜类化合物的化学性质。在模拟实际滴吸的条件下形成了甲基丙烯醛、苯和其他几种对人体健康有害的产物。观察到的萜类降解产物与大气化学文献中报道的一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a46a/6643865/b75d13f52824/ao-2017-01130a_0003.jpg

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