• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Defective human immunodeficiency virus (HIV) particles produced by cloned cells of HTLV-I-carrying MT-4 cells persistently infected with HIV.由持续感染HIV的携带HTLV-I的MT-4细胞的克隆细胞产生的有缺陷的人类免疫缺陷病毒（HIV）颗粒。
Jpn J Cancer Res. 1988 Apr;79(4):418-23. doi: 10.1111/j.1349-7006.1988.tb01607.x.
2
Production of infectious particles from defective human immunodeficiency virus type 1 (HIV-1)-producing cell clones by superinfection with infectious HIV-1.通过用感染性HIV-1进行超感染，从产生缺陷型1型人类免疫缺陷病毒（HIV-1）的细胞克隆中产生感染性颗粒。
Arch Virol. 1991;116(1-4):143-58. doi: 10.1007/BF01319238.
3
A new human retrovirus isolate of West African origin (SBL-6669) and its relationship to HTLV-IV, LAV-II, and HTLV-IIIB.一种源自西非的新型人类逆转录病毒分离株（SBL-6669）及其与HTLV-IV、LAV-II和HTLV-IIIB的关系。
AIDS Res Hum Retroviruses. 1987 Spring;3(1):3-10. doi: 10.1089/aid.1987.3.3.
4
Coexistence of fusion receptors for human T-cell leukemia virus type-I (HTLV-I) and human immunodeficiency virus type-1 (HIV-1) on MOLT-4 cells.人T细胞白血病病毒I型（HTLV-I）和人免疫缺陷病毒1型（HIV-1）的融合受体在MOLT-4细胞上共存。
Microbiol Immunol. 1991;35(9):729-40. doi: 10.1111/j.1348-0421.1991.tb01606.x.
5
Noninfectious doughnut-shaped human immunodeficiency virus type 1 can induce syncytia mediated by fusion of the particles with CD4-positive cells.非感染性1型人类免疫缺陷病毒呈甜甜圈状，可诱导病毒颗粒与CD4阳性细胞融合介导形成多核巨细胞。
J Acquir Immune Defic Syndr (1988). 1991;4(12):1233-40.
6
Biological characterization of a simian immunodeficiency virus-like retrovirus (HTLV-IV): evidence for CD4-associated molecules required for infection.一种猿猴免疫缺陷病毒样逆转录病毒（HTLV-IV）的生物学特性：感染所需的CD4相关分子的证据。
J Virol. 1988 Aug;62(8):2557-68. doi: 10.1128/JVI.62.8.2557-2568.1988.
7
The budding of defective human immunodeficiency virus type 1 (HIV-1) particles from cell clones persistently infected with HIV-1.
Arch Virol. 1990;111(1-2):87-101. doi: 10.1007/BF01310507.
8
Infection of human T-lymphotropic virus type-I (HTLV-I)-bearing MT-4 cells with HTLV-III (AIDS virus): chronological studies of early events.用人类嗜T淋巴细胞病毒III型（艾滋病病毒）感染携带人类嗜T淋巴细胞病毒I型（HTLV-I）的MT-4细胞：早期事件的时序研究
Virology. 1985 Oct 30;146(2):272-81. doi: 10.1016/0042-6822(85)90010-8.
9
Evaluation of the safety of blood products with respect to human immunodeficiency virus infection by using an HTLV-I-infected cell line (SKT-1B).
Jpn J Cancer Res. 1987 Apr;78(4):365-71.
10
Enhancement of human immunodeficiency virus type 1 infectivity by replacing the region including Env derived from defective particles with an ability to form particle-mediated syncytia in CD4+T cells.通过用在CD4+T细胞中形成颗粒介导的合胞体的能力替换包括源自缺陷颗粒的Env的区域来增强1型人类免疫缺陷病毒的感染性。
Microbes Infect. 2004 Aug;6(10):911-8. doi: 10.1016/j.micinf.2004.05.003.

引用本文的文献

1
Essential right heart physiology for the perioperative practitioner POQI IX: current perspectives on the right heart in the perioperative period.围手术期从业者必备的右心生理学知识：围手术期质量改进与患者安全倡议（POQI）IX：围手术期右心的当前观点
Perioper Med (Lond). 2024 Apr 9;13(1):27. doi: 10.1186/s13741-024-00378-8.
2
Amino acid 36 in the human immunodeficiency virus type 1 gp41 ectodomain controls fusogenic activity: implications for the molecular mechanism of viral escape from a fusion inhibitor.人类免疫缺陷病毒1型gp41胞外结构域中的36位氨基酸控制融合活性：对病毒逃逸融合抑制剂分子机制的启示。
J Virol. 2005 May;79(10):5996-6004. doi: 10.1128/JVI.79.10.5996-6004.2005.
3
Positive and negative aspects of the human immunodeficiency virus protease: development of inhibitors versus its role in AIDS pathogenesis.人类免疫缺陷病毒蛋白酶的正负两方面：抑制剂的研发与其在艾滋病发病机制中的作用
Microbiol Mol Biol Rev. 2000 Dec;64(4):725-45. doi: 10.1128/MMBR.64.4.725-745.2000.
4
Inhibition of HIV-1 replication and syncytium formation by synthetic CD4 peptides.合成CD4肽对HIV-1复制和合体形成的抑制作用。
Arch Virol. 1989;105(1-2):129-35. doi: 10.1007/BF01311123.
5
Characterization of human T-cell lines harboring defective human immunodeficiency virus type 1.
Virus Genes. 1989 Nov;3(2):141-52. doi: 10.1007/BF00125126.
6
A defective proviral DNA with a 2.6-kb deletion of human immunodeficiency virus type 1 (HIV-1) in a persistently HIV-1 infected cell clone.在一个持续感染1型人类免疫缺陷病毒（HIV-1）的细胞克隆中，存在一个有2.6千碱基对缺失的缺陷型前病毒DNA。
Virus Genes. 1991 Jan;5(1):81-8. doi: 10.1007/BF00571734.
7
Production of infectious particles from defective human immunodeficiency virus type 1 (HIV-1)-producing cell clones by superinfection with infectious HIV-1.通过用感染性HIV-1进行超感染，从产生缺陷型1型人类免疫缺陷病毒（HIV-1）的细胞克隆中产生感染性颗粒。
Arch Virol. 1991;116(1-4):143-58. doi: 10.1007/BF01319238.
8
Human immunodeficiency virus type 1 vif, vpr, and vpu mutants can produce persistently infected cells.1型人类免疫缺陷病毒的病毒感染因子（Vif）、病毒蛋白R（Vpr）和病毒蛋白U（Vpu）突变体能够产生持续感染的细胞。
Arch Virol. 1991;120(3-4):181-92. doi: 10.1007/BF01310474.
9
The budding of defective human immunodeficiency virus type 1 (HIV-1) particles from cell clones persistently infected with HIV-1.
Arch Virol. 1990;111(1-2):87-101. doi: 10.1007/BF01310507.

本文引用的文献

1
Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.成人T细胞白血病：一种成人T细胞白血病细胞系中的抗原及人血清中该抗原抗体的检测
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6476-80. doi: 10.1073/pnas.78.10.6476.
2
Quantitative separation of murine leukemia virus proteins by reversed-phase high-pressure liquid chromatography reveals newly described gag and env cleavage products.通过反相高压液相色谱法对小鼠白血病病毒蛋白进行定量分离，揭示了新描述的gag和env裂解产物。
J Virol. 1984 Nov;52(2):492-500. doi: 10.1128/JVI.52.2.492-500.1984.
3
Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells.通过将正常人脐带血白细胞与人类白血病T细胞共同培养而获得的脐带T细胞系中的C型病毒颗粒。
Nature. 1981 Dec 24;294(5843):770-1. doi: 10.1038/294770a0.
4
Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.从旧金山艾滋病患者中分离淋巴细胞病变逆转录病毒。
Science. 1984 Aug 24;225(4664):840-2. doi: 10.1126/science.6206563.
5
Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS.从艾滋病患者和艾滋病前期患者中检测、分离并持续生产细胞病变逆转录病毒（HTLV-III）。
Science. 1984 May 4;224(4648):497-500. doi: 10.1126/science.6200935.
6
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).从一名有获得性免疫缺陷综合征（艾滋病）风险的患者体内分离出一种嗜T淋巴细胞逆转录病毒。
Science. 1983 May 20;220(4599):868-71. doi: 10.1126/science.6189183.
7
T4 positive human neoplastic cell lines susceptible to and permissive for HTLV-III.对HTLV-III敏感且允许其感染的T4阳性人类肿瘤细胞系。
Lancet. 1984 Dec 22;2(8417-8418):1472-3. doi: 10.1016/s0140-6736(84)91666-0.
8
Inhibition of cleavage of Moloney murine leukemia virus gag and env coded precursor polyproteins by cerulenin.浅蓝菌素对莫洛尼鼠白血病病毒gag和env编码的前体多蛋白切割的抑制作用。
Virology. 1986 Oct 15;154(1):195-206. doi: 10.1016/0042-6822(86)90441-1.
9
Amplification of human immuno-deficiency virus production from a virus-producing cell line in culture at high cell density.在高细胞密度培养条件下，从病毒产生细胞系中扩增人类免疫缺陷病毒产量。
Jpn J Cancer Res. 1987 Jul;78(7):643-7.
10
Effect of HTLV-III on the macromolecular synthesis in HTLV-I carrying cell line, MT-4.
Med Microbiol Immunol. 1986;175(6):325-34. doi: 10.1007/BF02123869.

由持续感染HIV的携带HTLV-I的MT-4细胞的克隆细胞产生的有缺陷的人类免疫缺陷病毒（HIV）颗粒。

Defective human immunodeficiency virus (HIV) particles produced by cloned cells of HTLV-I-carrying MT-4 cells persistently infected with HIV.

作者信息

Ikuta K, Morita C, Nakai M, Yamamoto N, Kato S

机构信息

Department of Pathology, Osaka University.

出版信息

Jpn J Cancer Res. 1988 Apr;79(4):418-23. doi: 10.1111/j.1349-7006.1988.tb01607.x.

DOI:10.1111/j.1349-7006.1988.tb01607.x
PMID:2898463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917499/
Abstract

Persistently HIV-infected cell lines were isolated from surviving and proliferating cells after infection of HTLV-I-carrying MT-4 cells with cell-free human immunodeficiency virus (HIV); HTLV-IIIB and LAV. The media of the cloned cell cultures did not cause HIV infection of MT-4, MOLT-4, TALL-1, or HL-60 cells. Most of the constituents of the virus in the media were env proteins and many defective doughnut-shaped particles released from the cells were identified by electron microscopy.

摘要

在用无细胞人免疫缺陷病毒（HIV）感染携带HTLV - I的MT - 4细胞后，从存活并增殖的细胞中分离出持续感染HIV的细胞系；HTLV - IIIB和LAV。克隆细胞培养物的培养基不会导致MT - 4、MOLT - 4、TALL - 1或HL - 60细胞感染HIV。培养基中病毒的大多数成分是包膜蛋白，并且通过电子显微镜鉴定出许多从细胞中释放的有缺陷的甜甜圈状颗粒。