由持续感染HIV的携带HTLV-I的MT-4细胞的克隆细胞产生的有缺陷的人类免疫缺陷病毒（HIV）颗粒。
Defective human immunodeficiency virus (HIV) particles produced by cloned cells of HTLV-I-carrying MT-4 cells persistently infected with HIV.
作者信息
Ikuta K, Morita C, Nakai M, Yamamoto N, Kato S
机构信息
Department of Pathology, Osaka University.
出版信息
Jpn J Cancer Res. 1988 Apr;79(4):418-23. doi: 10.1111/j.1349-7006.1988.tb01607.x.
Abstract
Persistently HIV-infected cell lines were isolated from surviving and proliferating cells after infection of HTLV-I-carrying MT-4 cells with cell-free human immunodeficiency virus (HIV); HTLV-IIIB and LAV. The media of the cloned cell cultures did not cause HIV infection of MT-4, MOLT-4, TALL-1, or HL-60 cells. Most of the constituents of the virus in the media were env proteins and many defective doughnut-shaped particles released from the cells were identified by electron microscopy.
摘要
在用无细胞人免疫缺陷病毒（HIV）感染携带HTLV - I的MT - 4细胞后，从存活并增殖的细胞中分离出持续感染HIV的细胞系；HTLV - IIIB和LAV。克隆细胞培养物的培养基不会导致MT - 4、MOLT - 4、TALL - 1或HL - 60细胞感染HIV。培养基中病毒的大多数成分是包膜蛋白，并且通过电子显微镜鉴定出许多从细胞中释放的有缺陷的甜甜圈状颗粒。
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