Laboratory of Application of Chemistry to Natural Resources, Substances and the Environment (LACReSNE), Faculty of Sciences of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia; Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy University of Granada, Campus of Cartuja, 18071 s/n, Granada, Spain.
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy University of Granada, Campus of Cartuja, 18071 s/n, Granada, Spain.
Int J Biol Macromol. 2019 Apr 1;126:44-53. doi: 10.1016/j.ijbiomac.2018.12.205. Epub 2018 Dec 23.
Chitosan (CS) and purified sodium beidellite (Na-Bd) were used to obtain a nanocomposite able to carry anionic pharmaceutical ingredients. Diclofenac sodium (DS) was chosen as a model drug and was loaded by intercalation solution technique. Solid state characterization of the resultant hybrids was performed, including X-ray diffraction, Fourier transformed infrared spectroscopy, Thermal analysis and high resolution transmission electron microscopy coupled with energy dispersive X-Ray analysis. Drug loading capacity and encapsulation efficiency were quantified by measuring equilibrium concentration by UV-Vis spectroscopy at 276 nm. Solid-state characterization of the samples confirmed both chemical and physical interaction of DS with the nanocomposites. High drug loading along with a modified cumulative release of the drug in simulated intestinal fluid was obtained. The developed clay/polymer hybrids can act as potential candidates for the design of modified dosage forms of anionic drugs.
壳聚糖 (CS) 和纯化的钠皂石 (Na-Bd) 被用于获得能够携带阴离子药物成分的纳米复合材料。选择双氯芬酸钠 (DS) 作为模型药物，并通过插层溶液技术进行负载。通过 X 射线衍射、傅里叶变换红外光谱、热分析和高分辨率透射电子显微镜结合能谱对所得杂化物进行了固态表征。通过在 276nm 处测量 UV-Vis 光谱的平衡浓度来定量测定药物的载药量和包封效率。样品的固态表征证实了 DS 与纳米复合材料的化学和物理相互作用。在模拟肠液中获得了高载药量和药物累积释放的改良。开发的粘土/聚合物杂化物可用作设计阴离子药物的改良剂型的潜在候选物。
