Camley Brian A, Rappel Wouter-Jan
Department of Physics, UC San Diego, San Diego, CA, USA.
J Phys D Appl Phys. 2017;50(11). doi: 10.1088/1361-6463/aa56fe. Epub 2017 Feb 14.
In this article, we review physics-based models of collective cell motility. We discuss a range of techniques at different scales, ranging from models that represent cells as simple self-propelled particles to phase field models that can represent a cell's shape and dynamics in great detail. We also extensively review the ways in which cells within a tissue choose their direction, the statistics of cell motion, and some simple examples of how cell-cell signaling can interact with collective cell motility. This review also covers in more detail selected recent works on collective cell motion of small numbers of cells on micropatterns, in wound healing, and the chemotaxis of clusters of cells.
在本文中，我们回顾了基于物理学的集体细胞运动模型。我们讨论了不同尺度下的一系列技术，从将细胞表示为简单自推进粒子的模型到能够非常详细地表示细胞形状和动态的相场模型。我们还广泛回顾了组织内细胞选择方向的方式、细胞运动的统计数据，以及细胞间信号传导如何与集体细胞运动相互作用的一些简单示例。本综述还更详细地涵盖了近期关于微图案上少量细胞的集体细胞运动、伤口愈合以及细胞簇趋化性的部分研究工作。
